ArticleAnnals of internal medicine2013
Atrial ectopy as a predictor of incident atrial fibrillation: a cohort study.
Article in Annals of internal medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 104 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Coffee and Real-time Atrial and Ventricular Ectopy
Marijuana and Acute Risk of Arrhythmia- Joint Abstinence and Exposure
Who cites it
104 citing papers in PubMed, 4 syntheses or guidelines pooled it, 170 citations in OpenAlex.
- 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2024Guideline
- Guideline
- Excessive Supraventricular Ectopic Activity and Adverse Cardiovascular Outcomes: a Systematic Review and Meta-analysis.Current atherosclerosis reports · 2020Pooled it
- Relation of premature atrial complexes with stroke and death: Systematic review and meta-analysis.Clinical cardiology · 2017Pooled it
- Association of blood pressure control with atrial and ventricular ectopy in SPRINT.Open heart · 2025Trial
- Premature Atrial Contractions as a Marker of Atrial Cardiopathy: A Revised Analysis of the ARCADIA Randomized Trial.Journal of cardiovascular electrophysiology · 2025Trial
- Acute Effects of Coffee Consumption on Health among Ambulatory Adults.The New England journal of medicine · 2023Trial
- Brief episodes of rapid irregular atrial activity (micro-AF) are a risk marker for atrial fibrillation: a prospective cohort study.BMC cardiovascular disorders · 2020Trial
- The cardiac diagnostic work-up in stroke patients-A subanalysis of the Find-AFRANDOMISED trial.PloS one · 2019Trial
- A Pilot Randomized Trial of Oral Magnesium Supplementation on Supraventricular Arrhythmias.Nutrients · 2018Trial
- Atrial ectopy as a mediator of the association between race and atrial fibrillation.Heart rhythm · 2017Trial
- Fast atrial activity predicts recurrence of atrial fibrillation after pulmonary vein isolation: results from a prospective randomized study.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2015Trial
- AI-Enabled ECG Mapping to Guide Leadless Atrial Pacemaker Implantation in the Bachmann's Bundle Region.JACC. Case reports · 2026Article
- Obstructive Sleep Apnea and Arrhythmia: A Narrative Review of Arrhythmogenic Mechanisms.Diagnostics (Basel, Switzerland) · 2026Review
- Cardiac Responses to Alcohol: A Review of Mechanisms and Clinical Implications.Reviews in cardiovascular medicine · 2026Review
- Atrial fibrillation, sinoatrial and atrioventricular node dysfunction in a mouse model of heart failure with preserved ejection fraction.Experimental physiology · 2026Article
- Association between atrial premature beat and left atrial function in hypertrophic cardiomyopathy on cardiovascular magnetic resonance myocardial tissue tracking: a reproducibility cohort study.Quantitative imaging in medicine and surgery · 2026Article
- Power-law properties of nocturnal arrhythmia avalanches: A novel marker for incident cardiovascular events.Heart rhythm · 2025Article
- Relaxin-2 Exhibits a Beneficial Role in Energy Metabolism to Alleviate Atrial Fibrillation Susceptibility.ACS pharmacology & translational science · 2025Article
- Optimising the management of temporary epicardial atrial pacing to combat postoperative atrial fibrillation.The British journal of cardiology · 2025Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAtrial fibrillation (AF) prediction models have unclear clinical utility given the absence of AF prevention therapies and the immutability of many risk factors. Premature atrial contractions (PACs) play a critical role in AF pathogenesis and may be modifiable.
objectiveTo investigate whether PAC count improves model performance for AF risk.
designProspective cohort study.
setting4 U.S. communities. PATIENTS: A random subset of 1260 adults without prevalent AF enrolled in the Cardiovascular Health Study between 1989 and 1990. MEASUREMENTS: The PAC count was quantified by 24-hour electrocardiography. Participants were followed for the diagnosis of incident AF or death. The Framingham AF risk algorithm was used as the comparator prediction model.
resultsIn adjusted analyses, doubling the hourly PAC count was associated with a significant increase in AF risk (hazard ratio, 1.17 [95% CI, 1.13 to 1.22]; P < 0.001) and overall mortality (hazard ratio, 1.06 [CI, 1.03 to 1.09]; P < 0.001). Compared with the Framingham model, PAC count alone resulted in similar AF risk discrimination at 5 and 10 years of follow-up and superior risk discrimination at 15 years. The addition of PAC count to the Framingham model resulted in significant 10-year AF risk discrimination improvement (c-statistic, 0.65 vs. 0.72; P < 0.001), net reclassification improvement (23.2% [CI, 12.8% to 33.6%]; P < 0.001), and integrated discrimination improvement (5.6% [CI, 4.2% to 7.0%]; P < 0.001). The specificity for predicting AF at 15 years exceeded 90% for PAC counts more than 32 beats/h. LIMITATION: This study does not establish a causal link between PACs and AF.
conclusionThe addition of PAC count to a validated AF risk algorithm provides superior AF risk discrimination and significantly improves risk reclassification. Further study is needed to determine whether PAC modification can prospectively reduce AF risk. PRIMARY FUNDING SOURCE: American Heart Association, Joseph Drown Foundation, and National Institutes of Health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.