ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2013
Acoustic radiation force beam sequence performance for detection and material characterization of atherosclerotic plaques: preclinical, ex vivo results.
Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Hydrophone Spatial Averaging Correction for Acoustic Exposure Measurements From Arrays-Part I: Theory and Impact on Diagnostic Safety Indexes.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Delineation of Human Carotid Plaque Features In Vivo by Exploiting Displacement Variance.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2019Observational
- Development of an intravascular ultrasound elastography based on a dual-element transducer.Royal Society open science · 2018Article
- Performance of acoustic radiation force impulse ultrasound imaging for carotid plaque characterization with histologic validation.Journal of vascular surgery · 2017Article
- On the Feasibility of Quantifying Fibrous Cap Thickness With Acoustic Radiation Force Impulse (ARFI) Ultrasound.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2016Article
- Non-invasive in vivo characterization of human carotid plaques with acoustic radiation force impulse ultrasound: comparison with histology after endarterectomy.Ultrasound in medicine & biology · 2015Article
- Gene expression of catabolic inflammatory cytokines peak before anabolic inflammatory cytokines after ACL injury in a preclinical model.Journal of inflammation (London, England) · 2014Article
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Authors and funding
8 authors.
Funding
Abstract
This work presents preclinical data demonstrating performance of acoustic radiation force (ARF)-based elasticity imaging with five different beam sequences for atherosclerotic plaque detection and material characterization. Twelve trained, blinded readers evaluated parametric images taken ex vivo under simulated in vivo conditions of 22 porcine femoral arterial segments. Receiver operating characteristic (ROC) curve analysis was carried out to quantify reader performance using spatially-matched immunohistochemistry for validation. The beam sequences employed had high sensitivity (sens) and specificity (spec) for detecting Type III+ plaques (sens: 85%, spec: 79%), lipid pools (sens: 80%, spec: 86%), fibrous caps (sens: 86%, spec: 82%), calcium (sens: 96%, spec: 85%), collagen (sens: 78%, spec: 77%), and disrupted internal elastic lamina (sens: 92%, spec: 75%). 1:1 single-receive tracking yielded the highest median areas under the ROC curve (AUC), but was not statistically significantly higher than 4:1 parallel-receive tracking. Excitation focal configuration did not result in statistically different AUCs. Overall, these results suggest ARF-based imaging is relevant to detecting and characterizing plaques and support its use for diagnosing and monitoring atherosclerosis.
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