Evidence map›Paper›PMID 24296901›Full record

ArticleLab on a chip2014

Measuring single cell mass, volume, and density with dual suspended microchannel resonators.

Andrea K Bryan, Vivian C Hecht, Wenjiang Shen, Kristofor Payer, William H Grover, Scott R Manalis

Open access · greenAbstract read
In one paragraph

Article in Lab on a chip, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 188 citations in OpenAlex.

  1. Targeted cell deposition for lung re-endothelialization.Biomechanics and modeling in mechanobiology · 2026
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Andrea K Bryan *Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. scottm@media.mit.edu; ; Tel: +1-617-253-5039.
Vivian C Hecht *Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. scottm@media.mit.edu; ; Tel: +1-617-253-5039.
Wenjiang ShenInnovative Micro Technology, Santa Barbara, CA, 93117, USA.
Kristofor PayerMicrosystems Technology Laboratories, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
William H GroverDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. scottm@media.mit.edu; ; Tel: +1-617-253-5039.
Scott R ManalisDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. scottm@media.mit.edu; ; Tel: +1-617-253-5039.
Massachusetts Institute of Technology · USInnovative Micro Technology (United States) · US

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Paula T Hammond · 1985 to 2026
$93.9M
Systems Biology of Cell Decision ProcessesP50GM068762 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KEATING, AMY E · 2003 to 2012
$32.3M
TRANS-NETWORK PROJECTSU54CA143874 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI VAN OUDENAARDEN, ALEXANDER · 2009 to 2013
$15.1M
High throughput monitoring of mass, density and fluorescence of single cellsR01GM085457 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MANALIS, SCOTT R · 2008 to 2011
$1.2M
NCI NIH HHS P30 CA014051NCI NIH HHS P30-CA14051NCI NIH HHS U54 CA143874NCI NIH HHS U54CA143874NIGMS NIH HHS P50 GM068762NIGMS NIH HHS P50GM68762NIGMS NIH HHS R01 GM085457NIGMS NIH HHS R01GM085457
6 · The paper itself

Abstract

Cell size, measured as either volume or mass, is a fundamental indicator of cell state. Far more tightly regulated than size is density, the ratio between mass and volume, which can be used to distinguish between cell populations even when volume and mass appear to remain constant. Here we expand upon a previous method for measuring cell density involving a suspended microchannel resonator (SMR). We introduce a new device, the dual SMR, as a high-precision instrument for measuring single-cell mass, volume, and density using two resonators connected by a serpentine fluidic channel. The dual SMR designs considered herein demonstrate the critical role of channel geometry in ensuring proper mixing and damping of pressure fluctuations in microfluidic systems designed for precision measurement. We use the dual SMR to compare the physical properties of two well-known cancer cell lines: human lung cancer cell H1650 and mouse lymphoblastic leukemia cell line L1210.

Indexed as

Cell SizeAnimalsCell CountCell Line, TumorHumansMiceMicrofluidic Analytical TechniquesPovidoneSilicon DioxidePercollPovidoneSilicon Dioxide

Identifiers

PMID24296901
PMCPMC3895367
OpenAlexW2064460491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.