ArticleThe Journal of general virology2014
Novel hepatitis E like virus found in Swedish moose.
Article in The Journal of general virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 60 citations in OpenAlex.
- Trends and Challenges in the Detection and Environmental Surveillance of the Hepatitis E Virus.Microorganisms · 2025Review
- Article
- Hepatitis E Virus in Domestic Ruminants and Virus Excretion in Milk-A Potential Source of Zoonotic HEV Infection.Viruses · 2024Review
- Co-circulation of Hepatitis E Virus (HEV) Genotype 3 and Moose-HEV-Like Strains in Free-Ranging-Spotted Deer (Axis axis) in Uruguay.Food and environmental virology · 2023Article
- Current Knowledge of Hepatitis E Virus (HEV) Epidemiology in Ruminants.Pathogens (Basel, Switzerland) · 2022Review
- Hidden Viral Sequences in Public Sequencing Data and Warning for Future Emerging Diseases.mBio · 2021Article
- Mechanism of Cross-Species Transmission, Adaptive Evolution and Pathogenesis of Hepatitis E Virus.Viruses · 2021Review
- Seroprevalence of Hepatitis E Virus in Moose (Viruses · 2021Article
- Antibodies Against Hepatitis E Virus (HEV) in European Moose and White-Tailed Deer in Finland.Food and environmental virology · 2020Article
- Seroprevalence of Dromedary Camel HEV in Domestic and Imported Camels from Saudi Arabia.Viruses · 2020Article
- Small Animal Models of Hepatitis E Virus Infection.Cold Spring Harbor perspectives in medicine · 2019Review
- Article
- Genetic Variability and Evolution of Hepatitis E Virus.Viruses · 2019Review
- The Current Host Range of Hepatitis E Viruses.Viruses · 2019Review
- Hepatitis E virus strains infecting Swedish domestic pigs are unique for each pig farm and remain in the farm for at least 2 years.Transboundary and emerging diseases · 2019Article
- Evidence for an unknown agent antigenically related to the hepatitis E virus in dairy cows in the United States.Journal of medical virology · 2019Article
- Mode and tempo of human hepatitis virus evolution.Computational and structural biotechnology journal · 2019Review
- Evolutionary Origins of Enteric Hepatitis Viruses.Cold Spring Harbor perspectives in medicine · 2018Review
- Classification and Genomic Diversity of Enterically Transmitted Hepatitis Viruses.Cold Spring Harbor perspectives in medicine · 2018Review
- Origin and dispersal of Hepatitis E virus.Emerging microbes & infections · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel virus was detected in a sample collected from a Swedish moose (Alces alces). The virus was suggested as a member of the Hepeviridae family, although it was found to be highly divergent from the known four genotypes (gt1-4) of hepatitis E virus (HEV). Moose are regularly hunted for consumption in the whole of Scandinavia. Thus, the finding of this virus may be important from several aspects: (a) as a new diverged HEV in a new animal species, and (b) potential unexplored HEV transmission pathways for human infections. Considering these aspects, we have started the molecular characterization of this virus. A 5.1 kb amplicon was sequenced, and corresponded to the partial ORF1, followed by complete ORF2, ORF3 and poly(A) sequence. In comparison with existing HEVs, the moose HEV genome showed a general nucleotide sequence similarity of 37-63% and an extensively divergent putative ORF3 sequence. The junction region between the ORFs was also highly divergent; however, two putative secondary stem-loop structures were retained when compared to gt1-4, but with altered structural appearance. In the phylogenetic analysis, the moose HEV deviated and formed its own branch between the gt1-4 and other divergent animal HEVs. The characterization of this highly divergent genome provides important information regarding the diversity of HEV infecting various mammalian species. However, further studies are needed to investigate its prevalence in the moose populations and possibly in other host species, including the risk for human infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.