ArticleToxicology and applied pharmacology2014
Arsenic methylation and lung and bladder cancer in a case-control study in northern Chile.
Article in Toxicology and applied pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 6 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 6 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Environmental Nonessential Element Exposure and Urologic Cancer: A Systematic Review and Meta-Analysis.JAMA network open · 2026Pooled it
- Interaction between Occupational and Non-Occupational Arsenic Exposure and Tobacco Smoke on Lung Cancerogenesis: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults.The Cochrane database of systematic reviews · 2021Pooled it
- Arsenic Exposure and Risk of Urothelial Cancer: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence.Environmental health perspectives · 2017Pooled it
- Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2016Pooled it
- The Folic Acid and Creatine Trial: Treatment Effects of Supplementation on Arsenic Methylation Indices and Metabolite Concentrations in Blood in a Bangladeshi Population.Environmental health perspectives · 2023Trial
- Mendelian randomization analysis of arsenic metabolism and pulmonary function within the Hispanic Community Health Study/Study of Latinos.Scientific reports · 2021Trial
- Arsenic exposure at birth, socioeconomic status, and epigenetic aging among adults in northern Chile.Environmental research · 2026Article
- Speciation of Arsenic in Medium Containing Bacterial Strains ofInternational journal of environmental research and public health · 2025Article
- Spatial and temporal distribution of arsenic concentration in rural drinking water and health risk assessment in Northern China from 2013 to 2022: a case study of Inner Mongolia Autonomous Region.BMC public health · 2024Article
- Risk Factors Associated with Urothelial Bladder Cancer.International journal of environmental research and public health · 2024Review
- Nanomaterial-based optical colorimetric sensors for rapid monitoring of inorganic arsenic species: a review.Discover nano · 2024Review
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- Association between arsenic (+3 oxidation state) methyltransferase gene polymorphisms and arsenic methylation capacity in rural residents of northern China: a cross-sectional study.Archives of toxicology · 2023Article
- Arsenic and cancer: Evidence and mechanisms.Advances in pharmacology (San Diego, Calif.) · 2023Article
- Chemical Contamination in Bread from Food Processing and Its Environmental Origin.Molecules (Basel, Switzerland) · 2022Review
- A mass-balance approach to evaluate arsenic intake and excretion in different populations.Environment international · 2022Article
- Arsenic Speciation and Metallomics Profiling of Human Toenails as a Biomarker to Assess Prostate Cancer Cases: Atlantic PATH Cohort Study.Frontiers in public health · 2022Article
- A Call for Biomonitoring Systems in Latin America and the Caribbean: Considerations for Potentially Toxic Metals/Metalloids.Annals of global health · 2022Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
In humans, ingested inorganic arsenic is metabolized to monomethylarsenic (MMA) then to dimethylarsenic (DMA), although this process is not complete in most people. The trivalent form of MMA is highly toxic in vitro and previous studies have identified associations between the proportion of urinary arsenic as MMA (%MMA) and several arsenic-related diseases. To date, however, relatively little is known about its role in lung cancer, the most common cause of arsenic-related death, or about its impacts on people drinking water with lower arsenic concentrations (e.g., <200μg/L). In this study, urinary arsenic metabolites were measured in 94 lung and 117 bladder cancer cases and 347 population-based controls from areas in northern Chile with a wide range of drinking water arsenic concentrations. Lung cancer odds ratios adjusted for age, sex, and smoking by increasing tertiles of %MMA were 1.00, 1.91 (95% confidence interval (CI), 0.99-3.67), and 3.26 (1.76-6.04) (p-trend <0.001). Corresponding odds ratios for bladder cancer were 1.00, 1.81 (1.06-3.11), and 2.02 (1.15-3.54) (p-trend <0.001). In analyses confined to subjects only with arsenic water concentrations <200μg/L (median=60μg/L), lung and bladder cancer odds ratios for subjects in the upper tertile of %MMA compared to subjects in the lower two tertiles were 2.48 (1.08-5.68) and 2.37 (1.01-5.57), respectively. Overall, these findings provide evidence that inter-individual differences in arsenic metabolism may be an important risk factor for arsenic-related lung cancer, and may play a role in cancer risks among people exposed to relatively low arsenic water concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.