ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2014
Urine-based human papillomavirus DNA testing as a screening tool for cervical cancer in high-risk women.
Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic Test Accuracy of First-Void Urine Human Papillomaviruses for Presence Cervical HPV in Women: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Accuracy of urinary human papillomavirus testing for presence of cervical HPV: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2014Pooled it
- A Narrative Review of Urine-Based Human Papillomavirus Screening: Performance, Challenges, and Opportunities to Expand Access in the United States.Sexually transmitted diseases · 2025Review
- Comparison of Urine and Genital Samples for Detecting Human Papillomavirus (HPV) in Clinical Patients.Obstetrics and gynecology international · 2023Article
- ¡Habla de VPH! An Educational Activity for College Students in Puerto Rico.Puerto Rico health sciences journal · 2021Article
- Article
- The Utility of Urine-Based Sampling for Cervical Cancer Screening in Low-Resource Settings.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Cervical cancer detection by DNA methylation analysis in urine.Scientific reports · 2019Article
- Detection and genotyping of human papillomavirus virus (HPV): a comparative analysis of clinical performance in cervical and urine samples in Chilean women.International journal of clinical and experimental pathology · 2018Article
- A Versatile Nanowire Platform for Highly Efficient Isolation and Direct PCR-free Colorimetric Detection of Human Papillomavirus DNA from Unprocessed Urine.Theranostics · 2018Article
- Molecular Triage of Premalignant Lesions in Liquid-Based Cervical Cytology and Circulating Cell-Free DNA from Urine, Using a Panel of Methylated Human Papilloma Virus and Host Genes.Cancer prevention research (Philadelphia, Pa.) · 2016Article
- High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control Study.Gastroenterology research and practice · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo test the hypothesis that self-collected urine could be used to detect high-risk human papillomavirus (HPV) DNA with sensitivity and specificity comparable to those of standard cervical testing.
methodsWomen attending a gynecology clinic for evaluation of abnormal cytology were recruited. Fifty-two participants (21-60years of age) collected urine samples, and clinicians collected cervical brush samples. When appropriate, cervical biopsies were obtained during colposcopy. HPV detection and typing were performed on DNA extracts from each sample, using commercial reagents for L1 consensus polymerase chain reaction (PCR) and type-specific hybridization. HPV 16 viral load was determined by quantitative PCR in HPV 16-positive samples. A diagnostic test analysis was conducted for urine samples.
resultsFifty paired samples were analyzed, with 76% agreement between samples. The 12 discrepant pairs were all urine negative/cervix positive. The most common HPV types detected were 16, 51, 53, and 62. The urine test correctly identified 100% of the uninfected and 65% of the infected patients.
conclusionThe results indicate that HPV DNA detection using urine is less sensitive than cervical sampling in a population with abnormal cytology. Further exploration is warranted to determine clinical utility when other options are unavailable.
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