Evidence map›Paper›PMID 24296084›Full record

ArticleGenomics, proteomics & bioinformatics2013

Screening preeclamptic cord plasma for proteins associated with decreased breast cancer susceptibility.

Hoi Pang Low, Ashutosh Tiwari, Jagadeesh Janjanam, Li Qiu, Chien-I Chang, William C Strohsnitter, Errol R Norwitz, Sun W Tam, James E Evans, Karin M Green and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genomics, proteomics & bioinformatics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Hoi Pang LowDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Ashutosh TiwariDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931, USA.
Jagadeesh JanjanamDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931, USA.
Li QiuDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Chien-I ChangDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
William C StrohsnitterDepartment of Obstetrics and Gynecology, Tufts Medical Center, Boston, MA 02111, USA.
Errol R NorwitzDepartment of Obstetrics and Gynecology, Tufts Medical Center, Boston, MA 02111, USA.
Sun W TamProteomics and Mass Spectrometry Facility, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01545, USA.
James E EvansProteomics and Mass Spectrometry Facility, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01545, USA.
Karin M GreenProteomics and Mass Spectrometry Facility, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01545, USA.
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Mats LambeDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, SE171 77 Stockholm, Sweden.
Chung-Cheng HsiehDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: chung-cheng.hsieh@umassmed.edu.
University of Massachusetts Chan Medical School · USMichigan Technological University · USTufts Medical Center · USHarvard University · USKarolinska Institutet · SE

Funding

Stem Cells and Perinatal Factors for Breast Cancer RiskR01CA090902 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HSIEH, CHUNG-CHENG · 2002 to 2011
$3.3M
NCI NIH HHS R01 CA090902NCI NIH HHS R01CA090902
6 · The paper itself

Abstract

Preeclampsia, a complication of pregnancy characterized by hypertension and proteinuria, has been found to reduce the subsequent risk for breast cancer in female offspring. As this protective effect could be due to exposure to preeclampsia-specific proteins during intrauterine life, the proteomic profiles of umbilical cord blood plasma between preeclamptic and normotensive pregnancies were compared. Umbilical cord plasma samples, depleted of 14 abundant proteins, were subjected to proteomic analysis using the quantitative method of nanoACQUITY ultra performance liquid chromatography-mass spectrometry with elevated energy mode of acquisition(E) (NanoUPLC-MS(E)). Sixty-nine differentially expressed proteins were identified, of which 15 and 6 proteins were only detected in preeclamptic and normotensive pregnancies, respectively. Additionally, expression of 8 proteins (gelsolin, complement C5, keratin type I cytoskeletal 10, pigment epithelium-derived factor, complement factor B, complement component C7, hemoglobin subunit gamma-2 and alpha-fetoprotein) were up-regulated in preeclampsia with a fold change of ≥2.0 when compared to normotensive pregnancies. The identification of alpha-fetoprotein in preeclamptic umbilical cord blood plasma supported the validity of this screen as alpha-fetoprotein has anti-estrogenic properties and has previously been linked to preeclampsia as well as a reduced breast cancer risk. The findings of this pilot study may provide new insights into the mechanistic link between preeclampsia and potentially reduced breast cancer susceptibility in adult life.

Indexed as

ProteomicsBlood ProteinsBreast NeoplasmsChromatography, LiquidDisease SusceptibilityFemaleFetal BloodHumansMass SpectrometryPilot ProjectsPre-EclampsiaPregnancyBlood ProteinsBiomarkersIntrauterine environmentMass spectrometryPreeclampsiaPregnancyPrenatal

Identifiers

PMID24296084
PMCPMC4357835
OpenAlexW2040952591

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.