ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2014
Association between First Nations ethnicity and progression to kidney failure by presence and severity of albuminuria.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Reported sources of health inequities in Indigenous Peoples with chronic kidney disease: a systematic review of quantitative studies.BMC public health · 2021Pooled it
- Examining Inequities in Clinical Outcomes for Indigenous Patients Treated With Dialysis in Canada: A Scoping Review.Kidney medicine · 2025Review
- Article
- KRESCENT; 2005-2025 - 20 years! Editorial.Canadian journal of kidney health and disease · 2025Article
- Understanding the Current Landscape of Kidney Disease in Canada to Advance Precision Medicine Guided Personalized Care.Canadian journal of kidney health and disease · 2023Review
- Systemic Disease and Ocular Comorbidity Analysis of Geographically Isolated Federally Recognized American Indian Tribes of the Intermountain West.Journal of clinical medicine · 2020Article
- Ethnic minority disparities in progression and mortality of pre-dialysis chronic kidney disease: a systematic scoping review.BMC nephrology · 2020Article
- Preventing CKD in Developed Countries.Kidney international reports · 2020Review
- Burden, access, and disparities in kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Article
- Burden, access and disparities in kidney disease.Clinical kidney journal · 2019Article
- Burden, access, and disparities in kidney disease.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Burden, Access, and Disparities in Kidney Disease.Kidney diseases (Basel, Switzerland) · 2019Article
- Burden, Access, and Disparities in Kidney Disease.Kidney international reports · 2019Review
- Burden, access, and disparities in kidney disease.Journal of nephrology · 2019Article
- A Holistic Approach to Risk for Early Kidney Injury in Indigenous Youth With Type 2 Diabetes: A Proof of Concept Paper From the iCARE Cohort.Canadian journal of kidney health and disease · 2019Article
- Burden, Access, and Disparities in Kidney Disease.Canadian journal of kidney health and disease · 2019Article
- Screening for kidney disease in Indigenous Canadian children: The FINISHED screen, triage and treat program.Paediatrics & child health · 2018Article
- Peripheral artery disease among Indigenous Canadians: What do we know?Canadian journal of surgery. Journal canadien de chirurgie · 2018Review
- Remote Dwelling Location Is a Risk Factor for CKD Among Indigenous Canadians.Kidney international reports · 2018Article
- Exploring structural barriers to diabetes self-management in Alberta First Nations communities.Diabetology & metabolic syndrome · 2018Article
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10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundDespite a low prevalence of chronic kidney disease (estimated glomerular filtration rate [GFR]<60 mL/min per 1.73 m2), First Nations people have high rates of kidney failure requiring chronic dialysis or kidney transplantation. We sought to examine whether the presence and severity of albuminuria contributes to the progression of chronic kidney disease to kidney failure among First Nations people.
methodsWe identified all adult residents of Alberta (age≥18 yr) for whom an outpatient serum creatinine measurement was available from May 1, 2002, to Mar. 31, 2008. We determined albuminuria using urine dipsticks and categorized results as normal (i.e., no albuminuria), mild, heavy or unmeasured. Our primary outcome was progression to kidney failure (defined as the need for chronic dialysis or kidney transplantation, or a sustained doubling of serum creatinine levels). We calculated rates of progression to kidney failure by First Nations status, by estimated GFR and by albuminuria category. We determined the relative hazard of progression to kidney failure for First Nations compared with non-First Nations participants by level of albuminuria and estimated GFR.
resultsOf the 1 816 824 participants we identified, 48 669 (2.7%) were First Nations. First Nations people were less likely to have normal albuminuria compared with non-First Nations people (38.7% v. 56.4%). Rates of progression to kidney failure were consistently 2- to 3-fold higher among First Nations people than among non-First Nations people, across all levels of albuminuria and estimated GFRs. Compared with non-First Nations people, First Nations people with an estimated GFR of 15.0-29.9 mL/min per 1.73 m2 had the highest risk of progression to kidney failure, with similar hazard ratios for those with normal and heavy albuminuria.
interpretationAlbuminuria confers a similar risk of progression to kidney failure for First Nations and non-First Nations people.
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