Evidence map›Paper›PMID 24295637›Full record

ArticleEuropean journal of cancer (Oxford, England : 1990)2014

Functional single nucleotide polymorphisms of the RASSF3 gene and susceptibility to squamous cell carcinoma of the head and neck.

Hongguang Guo, Hongliang Liu, Jianhua Wei, Yangkai Li, Hongping Yu, Xiaoxiang Guan, Wang Li-E, Guojun Li, Erich M Sturgis, Qingyi Wei and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of cancer (Oxford, England : 1990), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Hongguang GuoDepartment of Otolaryngology and Head & Neck Surgery, Navy General Hospital, Beijing, China; Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Hongliang LiuDuke Cancer Institute, Duke University Medical Center, 905 South Lasalle Street, Durham, NC 27710, USA.
Jianhua WeiDepartment of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Yangkai LiDuke Cancer Institute, Duke University Medical Center, 905 South Lasalle Street, Durham, NC 27710, USA.
Hongping YuDepartment of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Xiaoxiang GuanDepartment of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Wang Li-EDepartment of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Guojun LiDepartment of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA; Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Erich M SturgisDepartment of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA; Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Qingyi WeiDuke Cancer Institute, Duke University Medical Center, 905 South Lasalle Street, Durham, NC 27710, USA. Electronic address: qingyi.wei@dm.duke.edu.
Zhensheng LiuDuke Cancer Institute, Duke University Medical Center, 905 South Lasalle Street, Durham, NC 27710, USA. Electronic address: zhensheng.liu@dm.duke.edu.
The University of Texas MD Anderson Cancer Center · USDuke Medical Center · USPLA Navy General Hospital · CN

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Targeting the p53 pathway for reversal of oral premalignancyP50CA097007 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MYERS, JEFFREY NICHOLAS · 2002 to 2012
$26.1M
Molecular Epidemiology of Head and Neck CancerR01ES011740 · NIEHS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2001 to 2012
$6.3M
Genotypes and Phenotypes of Apoptosis and Risk of Head and Neck CancerR01CA131274 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2009 to 2013
$3.0M
NCI NIH HHS CA 16672NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA097007NCI NIH HHS R01 CA 131274NCI NIH HHS R01 CA131274NIEHS NIH HHS R01 ES011740NIEHS NIH HHS R01 ES 11740
6 · The paper itself

Abstract

backgroundRASSF3 suppresses tumour formation through uncertain mechanisms, but it is an important gene of p53-dependent apoptosis. RASSF3 depletion impairs DNA repair after DNA damage, leading to polyploidy. The authors hypothesised that potential functional single-nucleotide polymorphisms (SNPs) of RASSF3 are associated with risk of squamous cell carcinoma of the head and neck (SCCHN).

methodsThe authors used a functional SNP approach to evaluate the associations between common (minor allele frequency⩾0.05), putative functional variants in RASSF3 and risk of SCCHN. Four selected such functional SNPs (rs6581580 T>G, rs7313765 G>A, rs12311754 G>C and rs1147098 T>C) in RASSF3 were identified and genotyped in 1087 patients and 1090 cancer-free controls in a non-Hispanic white population.

resultsThe authors found that two SNPs were significantly associated with SCCHN risk. Carriers of the variant rs6581580G and rs7313765A alleles were at a reduced SCCHN risk, compared with the corresponding common homozygotes [adjusted odds ratio (OR)=0.75 and 0.73 and 95% confidence interval (CI)=0.62-0.91 and 0.60-0.88, respectively, for dominant models; and Ptrend=0.012 and 0.041, respectively, for additive models], particularly for non-oropharyngeal tumours (adjusted OR=0.68 and 0.60 and 95% CI=0.53-0.86 and 0.47-0.77, respectively, for dominant models). In the genotype-phenotype correlation analysis of peripheral blood mononuclear cells from 102 cancer-free controls, the rs6581580 GG genotype was associated with significantly increased expression levels of RASSF3 mRNA (P=0.038), compared with the TT genotype. Additional functional experiments further showed that variant G allele of rs6581580 had a significantly stronger binding affinity to the nuclear protein extracts than the T allele.

conclusionTaken together, these findings indicate that the RASSF3 promoter rs6581580 T>G SNP is potentially functional, modulating susceptibility to SCCHN among non-Hispanic whites. Larger replication studies are needed to confirm our findings.

Indexed as

AgedBiomarkers, TumorCarcinoma, Squamous CellGene FrequencyGenes, Tumor SuppressorGenetic Predisposition to DiseaseGenotypeHead and Neck NeoplasmsHumansMaleMiddle AgedMonomeric GTP-Binding ProteinsPolymorphism, Single NucleotideRisk FactorsSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorMonomeric GTP-Binding ProteinsRASSF3 protein, humanApoptosisBiomarkerGenetic susceptibilityHead and neck cancerPolymorphismRASSF3

Identifiers

PMID24295637
PMCPMC3946894
OpenAlexW2048155402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.