ArticleBMC nephrology2013
Fluid overload in hemodialysis patients: a cross-sectional study to determine its association with cardiac biomarkers and nutritional status.
Article in BMC nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Bioimpedance-defined overhydration predicts survival in end stage kidney failure (ESKF): systematic review and subgroup meta-analysis.Scientific reports · 2018Pooled it
- Influence of dry weight reduction on anemia in patients undergoing hemodialysis.The Journal of international medical research · 2019Trial
- Efficacy of blood flow restriction exercise during dialysis for end stage kidney disease patients: protocol of a randomised controlled trial.BMC nephrology · 2017Trial
- Blood volume-monitored regulation of ultrafiltration to decrease the dry weight in fluid-overloaded hemodialysis patients: a randomized controlled trial.BMC nephrology · 2017Trial
- Adjudicating Heart Failure Events in Participants Receiving Hemodialysis: Findings from Evaluation of Cinacalcet Hydrochloride Therapy to Lower Cardiovascular Events (EVOLVE) Trial.American journal of nephrology · 2026Article
- The Dry-Weight Dilemma: Survey Results Based on a Qualitative Interview Study on Fluid Overload in Hemodialysis.Kidney medicine · 2026Article
- Subclinical overhydration predicts lower time in range and greater glycemic variability in type 2 diabetes on hemodialysis.Scientific reports · 2026Article
- Measurement of Skinfold Thickness in Subscapular Area to Monitor Hydration Status in Chronic Hemodialysis Patients.Kidney & blood pressure research · 2026Article
- Optimizing hemodialysis management using bioelectrical impedance analysis: emphasizing the significance of the phase angle.Renal failure · 2025Review
- Different Translational Activities of Inflammatory Regulators Associated with Hypervolemia in Haemodialysis Patients.International journal of molecular sciences · 2025Article
- Non-linear association between extracellular water/total body water ratio and all-cause mortality: a population-based cohort study.Scientific reports · 2025Article
- High NT pro-BNP levels in children with malignant disorder receiving intensive fluid treatment: a prospective comparative study.Frontiers in pediatrics · 2024Article
- Association between Intra- and Extra-Cellular Water Ratio Imbalance and Natriuretic Peptides in Patients Undergoing Hemodialysis.Nutrients · 2023Article
- Bioimpedance-Guided Monitoring of Volume Status in Patients With Kidney Disease: A Systematic Review and Meta-Analysis.Canadian journal of kidney health and disease · 2023Article
- Fluid Overload and Tissue Sodium Accumulation as Main Drivers of Protein Energy Malnutrition in Dialysis Patients.Nutrients · 2022Review
- Home-delivered meals as an adjuvant to improve volume overload and clinical outcomes in hemodialysis.Clinical kidney journal · 2022Article
- Prognostic values of high sensitivity cardiac troponin T and I for long-term mortality in hemodialysis patients.Scientific reports · 2022Article
- Detecting Volemic, Cardiac, and Autonomic Responses From Hypervolemia to NormovolemiaFrontiers in physiology · 2022Article
- Normal weight and waist obesity indicated by increased total body fat associated with all-cause mortality in stage 3-5 chronic kidney disease.Frontiers in nutrition · 2022Article
- Sodium First Approach, to Reset Our Mind for Improving Management of Sodium, Water, Volume and Pressure in Hemodialysis Patients, and to Reduce Cardiovascular Burden and Improve Outcomes.Frontiers in nephrology · 2022Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic fluid overload is associated with higher mortality in dialysis patients; however, the link with cardiovascular morbidity has not formally been established and may be influenced by subclinical inflammation. We hypothesized that a relationship exists between fluid overload and [i] cardiovascular laboratory parameter as well as between fluid overload and [ii] inflammatory laboratory parameters. In addition, we aimed to confirm whether volume status correlates with nutritional status.
methodsWe recorded baseline characteristics of 244 hemodialysis patients at three hemodialysis facilities in Vienna (Austria) and determined associations with volume measurements using the body composition monitor (Fresenius/Germany). In one facility comprising 126 patients, we further analyzed cardiovascular, inflammatory and nutritional parameters.
resultsWe detected predialysis fluid overload (FO) in 39% of all patients (n = 95) with FO defined as ≥15% of extracellular water (ECW). In this subgroup, the absolute FO was 4.4 +/-1.5 L or 22.9 ± 4.8% of ECW. A sub-analysis of patients from one center showed that FO was negatively associated with body mass index (r = -0.371; p = <0.001), while serum albumin was significantly lower in fluid overloaded patients (p = 0.001). FO was positively associated with D-Dimer (r = 0.316; p = 0.001), troponin T (r = 0.325; p < 0.001), and N-terminal pro-B-type natriuretic peptide (r = 0.436; p < 0.001), but not with investigated inflammatory parameters.
conclusionsFluid overload in HD patients was found to be lower in patients with high body mass index, indicating that dry weight was inadequately prescribed and/or difficult to achieve in overweight patients. The association with parameters of cardiovascular compromise and/or damage suggests that fluid overload is a biomarker for cardiovascular risk. Future studies should determine if this applies to patients prior to end-stage renal disease.
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