ArticleOrganic letters2014
An efficient, modular approach for the synthesis of (+)-strictifolione and a related natural product.
Article in Organic letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Recent Advances in the Stereoselective Total Synthesis of Natural Pyranones Having Long Side Chains.Molecules (Basel, Switzerland) · 2020Review
- Synthesis of 2-aminosuberic acid derivatives as components of some histone deacetylase inhibiting cyclic tetrapeptides.Beilstein journal of organic chemistry · 2017Article
- Synthesis of the C9-C25 Subunit of Spirastrellolide B.Organic letters · 2016Article
- Modular Synthesis of Novel Macrocycles Bearing α,β-Unsaturated Chemotypes through a Series of One-Pot, Sequential Protocols.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Phosphate Tether-Mediated Ring-Closing Metathesis for the Generation of P-Stereogenic, Z-Configured Bicyclo[7.3.1]- and Bicyclo[8.3.1]phosphates.The Journal of organic chemistry · 2016Article
- A Pot-Economical Approach to the Total Synthesis of Sch-725674.Organic letters · 2016Article
- Phosphate Tether-Mediated Ring-Closing Metathesis for the Generation of Medium to Large,Tetrahedron · 2015Article
- Synthetic Studies to Lyngbouilloside: A Phosphate Tether-Mediated Synthesis of the Macrolactone Core.Tetrahedron letters · 2015Article
- Enantioselective synthesis of spliceostatin E and evaluation of biological activity.Organic letters · 2014Article
- A modular phosphate tether-mediated divergent strategy to complex polyols.Beilstein journal of organic chemistry · 2014Article
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Authors and funding
3 authors.
Funding
Abstract
An efficient, library amenable, "pot economical" total synthesis of (+)-strictifolione and the related natural product, (6R)-6[(E,4R,6R)-4,6-dihydroxy-10-phenyl-1-decenyl]-5,6-dihydro-2H-2-pyrone, are reported. This modular approach takes advantage of two consecutive phosphate tether-mediated, one-pot, sequential protocols, followed by a final cross metathesis to deliver both antifungal natural products in a three-pot process from the respective enantiomeric (R,R)- and (S,S)-trienes with minimal purification. A salient feature of this route is that additional protecting groups are not required as a result of the orthogonal protecting- and leaving-group properties innate to phosphate triesters.
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