ArticleJournal of neurotrauma2014
Novel multi-system functional gains via task specific training in spinal cord injured male rats.
Article in Journal of neurotrauma, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 68 citations in OpenAlex.
- Spinal cord neuromodulation for autonomic recovery following spinal cord injury: a scoping review.Journal of neuroengineering and rehabilitation · 2026Article
- An environmental enrichment facilitates the recovery of lower urinary tract function after spinal cord injury through downmodulation of neurogenic activity in female rats.World journal of urology · 2026Article
- Beyond Transplantation: Engineering Neural Cell Therapies and Combination Strategies for Spinal Cord Repair.Brain sciences · 2026Review
- Catheterization Method and Functional Recovery of Neurogenic Bladder in Spinal Cord Injury.JAMA network open · 2025Article
- Daily electric field treatment improves functional outcomes after thoracic contusion spinal cord injury in rats.Nature communications · 2025Article
- Bladder Responses to Thoracolumbar Epidural Stimulation in Female Urethane-Anesthetized Rats with Graded Contusion Spinal Cord Injuries.Journal of neurotrauma · 2025Article
- Relevance of Leg Rehabilitation to Modulating Neurogenic Lower Urinary Tract Symptoms: A Systematic Review.Bioengineering (Basel, Switzerland) · 2025Review
- Review
- Differential effects of exercise and hormone treatment on spinal cord injury-induced changes in micturition and morphology of external urethral sphincter motoneurons.Restorative neurology and neuroscience · 2024Article
- The Role of Exercise in the Alleviation of Neuropathic Pain Following Traumatic Spinal Cord Injuries: A Systematic Review and Meta-analysis.Neurospine · 2023Article
- AAV Vector Mediated Delivery of NG2 Function Neutralizing Antibody and Neurotrophin NT-3 Improves Synaptic Transmission, Locomotion, and Urinary Tract Function after Spinal Cord Contusion Injury in Adult Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Attenuation of SCI-Induced Hypersensitivity by Intensive Locomotor Training and Recombinant GABAergic Cells.Bioengineering (Basel, Switzerland) · 2023Article
- Respiratory plasticity following spinal cord injury: perspectives from mouse to man.Neural regeneration research · 2022Review
- The Impact of Activity-Based Interventions on Neuropathic Pain in Experimental Spinal Cord Injury.Cells · 2022Review
- Article
- Serial transurethral cystometry: A novel method for longitudinal evaluation of reflex lower urinary tract function in adult female rats.Physiological reports · 2022Article
- Effect of T3 Spinal Contusion Injury on Upper Urinary Tract Function.Neurotrauma reports · 2022Article
- Effect of Different Forms of Activity-Based Recovery Training on Bladder, Bowel, and Sexual Function After Spinal Cord Injury.Archives of physical medicine and rehabilitation · 2021Article
- Exercise and Neuropathic Pain: A General Overview of Preclinical and Clinical Research.Sports medicine - open · 2021Review
- Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Locomotor training (LT) after spinal cord injury (SCI) is a rehabilitative therapy used to enhance locomotor recovery. There is evidence, primarily anecdotal, also associating LT with improvements in bladder function and reduction in some types of SCI-related pain. In the present study, we determined if a step training paradigm could improve outcome measures of locomotion, bladder function, and pain/allodynia. After a T10 contusive SCI trained animals (adult male Wistar rats), trained animals began quadrupedal step training beginning 2 weeks post-SCI for 1 h/day. End of study experiments (3 months of training) revealed significant changes in limb kinematics, gait, and hindlimb flexor-extensor bursting patterns relative to non-trained controls. Importantly, micturition function, evaluated with terminal transvesical cystometry, was significantly improved in the step trained group (increased voiding efficiency, intercontraction interval, and contraction amplitude). Because both SCI and LT affect neurotrophin signaling, and neurotrophins are involved with post-SCI plasticity in micturition pathways, we measured bladder neurotrophin mRNA. Training regulated the expression of nerve growth factor (NGF) but not BDNF or NT3. Bladder NGF mRNA levels were inversely related to bladder function in the trained group. Monitoring of overground locomotion and neuropathic pain throughout the study revealed significant improvements, beginning after 3 weeks of training, which in both cases remained consistent for the study duration. These novel findings, improving non-locomotor in addition to locomotor functions, demonstrate that step training post-SCI could contribute to multiple quality of life gains, targeting patient-centered high priority deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.