ReviewJournal of gastrointestinal oncology2013
Diet and supplements and their impact on colorectal cancer.
Review in Journal of gastrointestinal oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Coffee Consumption and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies.Nutrients · 2019Pooled it
- Dietary fibre for the prevention of recurrent colorectal adenomas and carcinomas.The Cochrane database of systematic reviews · 2017Pooled it
- Dietary flavonoid intake and the risk of digestive tract cancers: a systematic review and meta-analysis.Scientific reports · 2016Pooled it
- Assessment of Fecal Microbiota in Healthy Dogs and Dogs with Cutaneous Mast Cell Tumors Treated with Electrochemotherapy Combined with Gene Electrotransfer of IL-12.Veterinary sciences · 2026Article
- Bardoxolone methyl suppressed colorectal cancer cells in vitro by inhibiting the PI3K signaling pathway.Scientific reports · 2025Article
- Preoperative oxidative stress as a biomarker of postoperative complications in colorectal cancer patients.Przeglad gastroenterologiczny · 2025Article
- Association of spicy food consumption with colorectal polyp and adenoma prevalence: findings from the Lanxi Pre-Colorectal Cancer Cohort (LP3C).Frontiers in nutrition · 2025Article
- A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer.Current issues in molecular biology · 2024Review
- Associations between diet and nutritional supplements and colorectal cancer: A systematic review.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Role of the intestinal microbiota and diet in the onset and progression of colorectal and breast cancers and the interconnection between both types of tumours.Microbiome research reports · 2024Review
- Association of soy intake and cooking methods with colorectal polyp and adenoma prevalence: findings from the extended Lanxi pre-colorectal cancer cohort (LP3C).Frontiers in nutrition · 2024Article
- Article
- Butyrate-mediated Resistance to Trichostatin A Accompanied by Elevated Expression of Glucose Transporter 3 (GLUT3) in Human Colorectal Carcinoma HCT116 Cells.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Article
- Composite dietary antioxidant index and the risk of colorectal cancer: Findings from the Singapore Chinese Health Study.International journal of cancer · 2022Article
- Anticancer Effects of Lingonberry and Bilberry on Digestive Tract Cancers.Antioxidants (Basel, Switzerland) · 2021Review
- Gut Microbiota and Colorectal Cancer Development: A Closer Look to the Adenoma-Carcinoma Sequence.Biomedicines · 2020Review
- Epidemiology of Colorectal Cancer and the Risk Factors in Kermanshah Province-Iran 2009-2014.Journal of gastrointestinal cancer · 2019Article
- Review
- Tissue and Serum Trace Elements Concentration among Colorectal Patients: A Systematic Review of Case-Control Studies.Iranian journal of public health · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal cancer is the third commonest cancer and the third leading cause of cancer death among men and women. It has been proposed that dietary factors are responsible for 70-90% of colorectal cancer and diet optimization may prevent most cases.
aimTo evaluate the role of dietary components and supplements in colorectal cancer.
methodsBibliographical searches were performed in Pubmed for the terms "diet and colorectal cancer", "diet and colon cancer", "diet and rectal cancer", "nutrition and colorectal cancer", "probiotics and colorectal cancer", "prebiotics and colorectal cancer", "alcohol and cancer" and "colorectal cancer epidemiology".
resultsConsumption of processed or red meat, especially when cooked at high temperatures may be associated with increased risk of colorectal cancer. The evidence for dietary fibre is unclear but foods that contain high amounts of fibre are usually rich in polyphenols which have been shown to alter molecular processes that can encourage colorectal carcinogenesis. Meta-analyses provide evidence on the benefits of circulating, diet-derived and supplemented, vitamin D and Calcium. We also found that diets rich in Folate may prevent colorectal carcinoma. The evidence on dietary micronutrients such as Zinc and Selenium in association with colorectal cancer is not conclusive. It has been suggested that there may be a direct association between alcohol intake and colorectal cancer. In vitro and in vivo studies have highlighted a possible protective role of prebiotics and probiotics.
conclusionsThe lack of randomized trials and the presence of confounding factors including smoking, physical activity, obesity and diabetes may often yield inconclusive results. Carefully designed randomized trials are recommended.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.