ArticleInternational journal of clinical and experimental pathology2013
Increased ZO-1 expression predicts valuable prognosis in non-small cell lung cancer.
Article in International journal of clinical and experimental pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
- High expression of tight junction protein 1 as a predictive biomarker for bladder cancer grade and staging.Scientific reports · 2022Article
- Methylation of the Promoter Region of the Tight Junction Protein-1 by DNMT1 Induces EMT-like Features in Multiple Myeloma.Molecular therapy oncolytics · 2020Article
- CD2AP inhibits metastasis in gastric cancer by promoting cellular adhesion and cytoskeleton assembly.Molecular carcinogenesis · 2020Article
- Expression of Tight Junction Proteins Is Altered in Bladder Cancer.Analytical cellular pathology (Amsterdam) · 2020Article
- Dynamic transition of the blood-brain barrier in the development of non-small cell lung cancer brain metastases.Oncotarget · 2019Article
- High expression of Nectin-4 is associated with unfavorable prognosis in gastric cancer.Oncology letters · 2018Article
- Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC).Scientific reports · 2018Article
- MicroRNA‑103 regulates tumorigenesis in colorectal cancer by targeting ZO‑1.Molecular medicine reports · 2018Article
- Blood Vessel Epicardial Substance (BVES) in junctional signaling and cancer.Tissue barriers · 2018Review
- KLF15 promotes the proliferation and metastasis of lung adenocarcinoma cells and has potential as a cancer prognostic marker.Oncotarget · 2017Article
- Comparative Network Analysis of Patients with Non-Small Cell Lung Cancer and Smokers for Representing Potential Therapeutic Targets.Scientific reports · 2017Article
- LAMP1 expression is associated with poor prognosis in breast cancer.Oncology letters · 2017Article
- Identification of microRNA differentially expressed in three subtypes of non-small cell lung cancer and in silico functional analysis.Oncotarget · 2017Article
- High Eg5 expression predicts poor prognosis in breast cancer.Oncotarget · 2017Article
- High KIF2A expression predicts unfavorable prognosis in diffuse large B cell lymphoma.Annals of hematology · 2017Article
- High expression levels of Wnt5a and Ror2 in laryngeal squamous cell carcinoma are associated with poor prognosis.Oncology letters · 2017Article
- Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1-fibronectin links.Molecular biology of the cell · 2017Article
- Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner.Nucleic acids research · 2017Article
- High expression of LAMP1 as a prognostic marker in patients with epithelial ovarian cancer.International journal of clinical and experimental pathology · 2017Article
- Elevated expression of FABP3 and FABP4 cooperatively correlates with poor prognosis in non-small cell lung cancer (NSCLC).Oncotarget · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to investigate the expression of Zonula Occludens-1 (ZO-1) and its potential value as prognostic indicator of survival in patients with primary non-small cell lung cancer (NSCLC).
methodsQuantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry with tissue microarrays were used to characterize the expression of the ZO-1 mRNA and protein in NSCLC. The correlation of ZO-1 expression with clinical characteristics and prognosis was determined by statistical analysis.
resultsThe ZO-1 mRNA and protein levels were significantly lower in NSCLC tissue compared with corresponding peritumoral tissue (P<0.05). ZO-1 protein expression in NSCLC was related to age (P=0.042) and 5-year survival (P<0.001). Kaplan-Meier survival and Cox regression analyses revealed that low ZO-1 expression (P<0.001) and later stage grouping by TNM (P=0.031) were independent factors predicting poor prognosis for patients with NSCLC.
conclusionsOur findings provide the first evidence that high expression of ZO-1 is associated with good prognosis in NSCLC.
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24294375PMC3843269W1826253058What OpenQuestion holds
Registered trials
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