ArticleInternational journal of clinical and experimental pathology2013
Effects and interactions of MiR-577 and TSGA10 in regulating esophageal squamous cell carcinoma.
Article in International journal of clinical and experimental pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Jmjd2c maintains the ALDHCancer biology & therapy · 2024Article
- Exploring TSGA10 Function: A Crosstalk or Controlling Mechanism in the Signaling Pathway of Carcinogenesis?Cancers · 2024Review
- Oncogenic role and potential regulatory mechanism of fatty acid binding protein 5 based on a pan-cancer analysis.Scientific reports · 2023Article
- CXCL5/NF-Journal of oncology · 2021Article
- Article
- Expression of Testis-Specific Gene Antigen 10 (TSGA10) is Associated with Apoptosis and Cell Migration in Bladder Cancer Cells and Tumor Stage and Overall Survival in Patients with Bladder Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Comprehensive characterization of cancer-testis genes in testicular germ cell tumor.Cancer medicine · 2019Article
- miR-577 Regulates TGF-β Induced Cancer Progression through a SDPR-Modulated Positive-Feedback Loop with ERK-NF-κB in Gastric Cancer.Molecular therapy : the journal of the American Society of Gene Therapy · 2019Article
- Identification of nine microRNAs as potential biomarkers for lung adenocarcinoma.FEBS open bio · 2019Article
- miR-143 inhibits migration and invasion through regulating LASP1 in human esophageal cancer.International journal of clinical and experimental pathology · 2019Article
- Functional expression and impact of testis-specific gene antigen 10 in breast cancer: a combined in vitro and in silico analysis.BioImpacts : BI · 2019Article
- miR-577 suppresses cell proliferation and epithelial-mesenchymal transition by regulating the WNT2B mediated Wnt/β-catenin pathway in non-small cell lung cancer.Molecular medicine reports · 2018Article
- Article
- How interacting pathways are regulated by miRNAs in breast cancer subtypes.BMC bioinformatics · 2016Article
- KDM4C, a H3K9me3 Histone Demethylase, is Involved in the Maintenance of Human ESCC-Initiating Cells by Epigenetically Enhancing SOX2 Expression.Neoplasia (New York, N.Y.) · 2016Article
- The role of microRNA in esophageal squamous cell carcinoma.Journal of gastroenterology · 2016Review
- microRNA-186 inhibits cell proliferation and induces apoptosis in human esophageal squamous cell carcinoma by targeting SKP2.Laboratory investigation; a journal of technical methods and pathology · 2016Article
- MicroRNA-577 inhibits gastric cancer growth by targeting E2F transcription factor 3.Oncology letters · 2015Article
- MicroRNA-126 is down-regulated in human esophageal squamous cell carcinoma and inhibits the proliferation and migration in EC109 cell via PI3K/AKT signaling pathway.International journal of clinical and experimental pathology · 2015Article
- MicroRNAs as oncogenes or tumour suppressors in oesophageal cancer: potential biomarkers and therapeutic targets.Cell proliferation · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Testis specific 10 (TSGA10) was originally identified as a testis-specific protein and tumor-associated antigen in a number of cancer types. In this study, we found that down-regulation of TSGA10 was associated with increased malignancy and clinical features of esophageal squamous cell carcinomas (ESCCs). Moreover, increased expression of TSGA10 inhibited, while its knockdown promoted, tumor formation in vivo in nude mice. At the 3'UTR of the TSGA10 gene we identified two binding sites for microRNA-577 (miR-577). Further investigation demonstrated that expression levels of miR-577 and TSGA10 were negatively correlated to each other in ESCC cell lines and tumor samples. Moreover, manipulation of miR-577 and TSGA10 expression confirmed that miR-577 can regulate TSGA10 and in turn affect cell proliferation in vitro. Additionally, with flow cytometry and manipulation of the mir-577/TSGA10 axis, it was found that mir-577/TSGA10 axis influenced the growth of ESCC through regulating the G1-S phase transition. We also obtained evidence to establish that mir-577/TSGA10 axis activation was always accompanied by inactivation of the p53 pathway or the Rb pathway or both, thus, the latter two pathways are obligatory for progression of ESCCs with mir-577/TSGA10 axis activation. In addition, we found that such an interactive pathway in regulating cancer cell proliferation was restricted to a few cancer types including ESCC, but not uniformly applicable to other cancer types. This newly discovered regulatory mechanism provides a new dimension for ESCC diagnosis and therapy.
Indexed as
Identifiers
24294352PMC3843246W179313026What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.