ArticleJournal of children's orthopaedics2012
Prevalence of vitamin D insufficiency in Swiss teenagers with appendicular fractures: a prospective study of 100 cases.
Article in Journal of children's orthopaedics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Association of serum 25(OH)Vit-D levels with risk of pediatric fractures: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Pooled it
- Prevalence of vitamin D inadequacy in athletes: a systematic-review and meta-analysis.Sports medicine (Auckland, N.Z.) · 2015Pooled it
- Does Vitamin D Concentration Matter? The Consequential Effects of Serum Vitamin D Concentration and Supplementation on Paediatric Fracture Risk.Nutrients · 2026Article
- The effect of vitamin D on the speed and quality of pediatric fracture healing.Journal of children's orthopaedics · 2025Article
- Vitamin D Levels During Fracture Healing in Children.Physiological research · 2024Article
- Article
- Comparison of 25-OH vitamin D levels between children with upper and those with lower extremity fractures: A prospective case-control study.Acta orthopaedica et traumatologica turcica · 2022Article
- Vitamin D levels and fracture risk among Hispanic children.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2019Article
- Trends in the seasonal variation of paediatric fractures.Journal of children's orthopaedics · 2018Article
- Associations of Low Vitamin D and Elevated Parathyroid Hormone Concentrations With Bone Mineral Density in Perinatally HIV-Infected Children.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Vitamin D and Fracture Risk in Early Childhood: A Case-Control Study.American journal of epidemiology · 2017Article
- Prevalence of vitamin D insufficiency in children with forearm fractures.Journal of children's orthopaedics · 2017Article
- Vitamin D Deficiency in Pediatric Fracture Patients: Prevalence, Risk Factors, and Vitamin D Supplementation.Journal of clinical research in pediatric endocrinology · 2016Article
- Vitamin D and spine surgery.World journal of orthopedics · 2016Review
- Vitamin D and skeletal health in infancy and childhood.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe significance of subclinical vitamin D deficiency in the pathogenesis of fractures in children and adolescents currently remains unclear.
objectiveWe aimed to determine the prevalence of vitamin D insufficiency and its effect on bone mineral density (BMD) and bone mineral content (BMC) values in a collective of Swiss Caucasian children with a first episode of appendicular fracture. DESIGN AND
methodsOne hundred teenagers with a first episode of appendicular fracture [50 upper limb fractures (group 1) and 50 lower limb fractures (group 2)] and 50 healthy controls (group 3) were recruited into a cross-sectional study. The BMC and BMD values were measured by dual-energy X-ray absorptiometry, and serum 25 hydroxyvitamin D [25(OH)D] was assessed by electrochemiluminescence immunoassays.
resultsFrom the 100 injured teenagers in the study, 12 % had deficient vitamin D levels (<20 ng/mL; <50 nmol/L) and 36 % had insufficient levels (≥20 <30 ng/mL; ≥50 <78 nmol/L), whereas 6 and 34 % of healthy controls were, respectively, vitamin D deficient and insufficient. There were no significant differences for serum 25(OH)D levels, L2-L4 BMD Z-score, and L2-L4 BMC Z-score variables (p = 0.216) between the three groups nor for the calcaneal BMD Z-score variables (p = 0.278) between healthy controls and lower limb fracture victims. Investigations on the influences of serum 25(OH)D on BMD and BMC showed no correlation between serum 25(OH)D and L2-L4 BMD Z-scores (r = -0.15; p = 0.135), whereas low but significant inverse correlations were, surprisingly, detected between serum 25(OH)D and calcaneal BMD Z-scores (r = -0.21; p = 0.034) and between serum 25(OH)D and L2-L4 BMC Z-scores (r = -0.22; p = 0.029).
conclusionsA significant proportion of Swiss Caucasian teenagers were vitamin D insufficient, independent of limb fracture status, in our study. However, this study failed to show an influence of low vitamin D status on BMD and/or BMC of the lumbar spine and heel.
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