ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2013
Plasmid-mediated quinolone resistance (PMQR) and mutations in the topoisomerase genes of Salmonella enterica strains from Brazil.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 42 citations in OpenAlex.
- Epidemiological, Phenotypic, and Genomic Characterization ofMicroorganisms · 2026Article
- Acquisition of novel antibiotic resistance genes by the bacterial predator Bacteriovorax sp. As-1.The ISME journal · 2025Article
- Global trends in typhoid and paratyphoid, and invasive non-typhoidalFrontiers in medicine · 2025Article
- Characterization of plasmid-mediated quinolone resistance genes and extended-spectrum beta-lactamases in non-typhoidalVeterinary world · 2022Article
- Antibiotic Resistance in Non-TyphoidalPathogens (Basel, Switzerland) · 2022Article
- Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases ofAntibiotics (Basel, Switzerland) · 2021Review
- Antimicrobial Resistance and Whole-Genome Characterisation of High-Level Ciprofloxacin-ResistantInternational journal of molecular sciences · 2021Article
- Antimicrobial Resistance in Farm Animals in Brazil: An Update Overview.Animals : an open access journal from MDPI · 2020Review
- Draft Genome Sequences of 26Microbiology resource announcements · 2020Article
- Draft Genome Sequences of 30 Salmonella enterica Serovar Enteritidis Isolates Associated with Multiple Outbreaks in Brazil.Microbiology resource announcements · 2020Article
- Article
- Transmission of Chromosomal MDR DNA Fragment Encoding Ciprofloxacin Resistance by a Conjugative Helper Plasmid inFrontiers in microbiology · 2020Article
- Salmonellosis detection and evidence of antibiotic resistance in an urban raccoon population in a highly populated area, Costa Rica.Zoonoses and public health · 2019Article
- Molecular epidemiology and antimicrobial resistance of invasive non-typhoidalInfection and drug resistance · 2019Article
- Article
- Evolution and transmission of a conjugative plasmid encoding both ciprofloxacin and ceftriaxone resistance in Salmonella.Emerging microbes & infections · 2019Article
- Quinolone resistance phenotype and genetic characterization of Salmonella enterica serovar Pullorum isolates in China, during 2011 to 2016.BMC microbiology · 2018Article
- Quinolone susceptibility and genetic characterization ofLaboratory animal research · 2017Article
- Phenotypic and Genotypic Eligible Methods forFrontiers in microbiology · 2017Review
- Plasmid-mediated quinolone resistance.Microbiology spectrum · 2014Review
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to identify mutations in the Quinolone Resistance Determining sources Regions (QRDR) of the gyrA, gyrB, parC, and parE genes and to determine if any of the qnr variants or the aac(6')-Ib-cr variant were present in strains of Salmonella spp. isolated in Brazil. A total of 126 Salmonella spp. strains from epidemic (n = 114) and poultry (n = 12) origin were evaluated. One hundred and twelve strains (88.8%) were resistant to nalidixic acid (NAL) and 29 (23.01%) showed a reduced susceptibility to ciprofloxacin (Cip). The mutations identified were substitutions limited to the QRDR of the gyrA gene in the codons for Serine 83, Aspartate 87 and Alanine 131. The sensitivity to NAL seems to be a good phenotypic indication of distinguishing mutated and non-mutated strains in the QRDR, however the double mutation in gyrA did not cause resistance to ciprofloxacin. The qnrA1 and qnrB19 genes were detected, respectively, in one epidemic strain of S. Enteritidis and one strain of S. Corvallis of poultry origin. Despite previous detection of qnr genes in Brazil, this is the first report of qnr gene detection in Salmonella, and also the first detection of qnrB19 gene in this country. The results alert for the continuous monitoring of quinolone resistance determinants in order to minimize the emergence and selection of Salmonella spp. strains showing reduced susceptibility or resistance to quinolones.
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