ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2013
Yeast biomass production: a new approach in glucose-limited feeding strategy.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Acetic acid induces strain-specific metabolic adaptation ofBiotechnology reports (Amsterdam, Netherlands) · 2026Article
- Metabolic Responses ofACS omega · 2026Article
- Evaluation of Cell Responses ofMicroorganisms · 2023Article
- Optimization, characterization, comparison of self-assembly VLP of capsid protein L1 in yeast and reverse vaccinology design against human papillomavirus type 52.Journal, genetic engineering & biotechnology · 2023Article
- Analysis of Gluten in Dried Yeast and Yeast-Containing Products.Foods (Basel, Switzerland) · 2020Article
- Autolysis, plasmolysis and enzymatic hydrolysis of baker's yeast (Saccharomyces cerevisiae): a comparative study.World journal of microbiology & biotechnology · 2020Article
- Effects of glucose concentration on 1,18-cis-octadec-9-enedioic acid biotransformation efficiency and lipid body formation in Candida tropicalis.Scientific reports · 2017Article
- Achieving Metabolic Flux Analysis for S. cerevisiae at a Genome-Scale: Challenges, Requirements, and Considerations.Metabolites · 2015Review
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3 authors.
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Abstract
The aim of this work was to implement experimentally a simple glucose-limited feeding strategy for yeast biomass production in a bubble column reactor based on a spreadsheet simulator suitable for industrial application. In biomass production process using Saccharomyces cerevisiae strains, one of the constraints is the strong tendency of these species to metabolize sugars anaerobically due to catabolite repression, leading to low values of biomass yield on substrate. The usual strategy to control this metabolic tendency is the use of a fed-batch process in which where the sugar source is fed incrementally and total sugar concentration in broth is maintained below a determined value. The simulator presented in this work was developed to control molasses feeding on the basis of a simple theoretical model in which has taken into account the nutritional growth needs of yeast cell and two input data: the theoretical specific growth rate and initial cell biomass. In experimental assay, a commercial baker's yeast strain and molasses as sugar source were used. Experimental results showed an overall biomass yield on substrate of 0.33, a biomass increase of 6.4 fold and a specific growth rate of 0.165 h(-1) in contrast to the predicted value of 0.180 h-1 in the second stage simulation.
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