ArticleFrontiers in aging neuroscience2013
Age differences in the intrinsic functional connectivity of default network subsystems.
Article in Frontiers in aging neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
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Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analytic evidence that mindfulness training alters resting state default mode network connectivity.Scientific reports · 2022Pooled it
- Baseline Functional Connectivity in Resting State Networks Associated with Depression and Remission Status after 16 Weeks of Pharmacotherapy: A CAN-BIND Report.Cerebral cortex (New York, N.Y. : 1991) · 2022Trial
- Changes in Neural Connectivity and Memory Following a Yoga Intervention for Older Adults: A Pilot Study.Journal of Alzheimer's disease : JAD · 2016Trial
- Reliability of Task-Based fMRI for Preoperative Planning: A Test-Retest Study in Brain Tumor Patients and Healthy Controls.PloS one · 2016Trial
- Tetrix: A novel Tetris-based paradigm for neuroimaging research and clinical applications.Behavior research methods · 2026Article
- Age-Related Low Frequency Amplitude Differences in Resting-State Blood Oxygenation Level-Dependent Signal in the Cerebellum.Human brain mapping · 2026Article
- How alexithymia shapes functional networks: Insights from a general population study.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Altered static and dynamic functional network connectivity between subcortical nuclei and cortical regions of the default mode network in type 2 diabetes mellitus.Frontiers in neuroscience · 2026Article
- Age-Related Differences in Resting-State Functional Connectivity Predict Specific Patterns of Speech Disfluency.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Hippocampal Drift Rate Reflects the Temporal Organization of Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The effects of sex and age on movie-watching functional connectivity and movie clip classification.Brain structure & function · 2025Article
- Relations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis.Schizophrenia research · 2025Article
- A novel scoring protocol reveals age-related differences in abstract compared to concrete thinking in cued autobiographical remembering.Scientific reports · 2024Article
- Common and unique brain aging patterns between females and males quantified by large-scale deep learning.Human brain mapping · 2024Article
- Changes in Spatiotemporal Dynamics of Default Network Oscillations between 19 and 29 Years of Age.Brain sciences · 2024Article
- Article
- A within-subject voxel-wise constant-block partial least squares correlation method to explore MRI-based brain structure-function relationship.Cognitive neurodynamics · 2024Article
- Single voxel autocorrelation uncovers gradients of temporal dynamics in the hippocampus and entorhinal cortex during rest and navigation.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The effects of typical ageing on cognitive control: recent advances and future directions.Frontiers in aging neuroscience · 2023Review
- Dissociable neural mechanisms of cognition and well-being in youth versus healthy aging.Psychology and aging · 2022Article
16 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
Recent work suggests that the default mode network (DMN) includes two core regions, the ventromedial prefrontal cortex and posterior cingulate cortex (PCC), and several unique subsystems that are functionally distinct. These include a medial temporal lobe (MTL) subsystem, active during remembering and future projection, and a dorsomedial prefrontal cortex (dmPFC) subsystem, active during self-reference. The PCC has been further subdivided into ventral (vPCC) and dorsal (dPCC) regions that are more strongly connected with the DMN and cognitive control networks, respectively. The goal of this study was to examine age differences in resting state functional connectivity within these subsystems. After applying a rigorous procedure to reduce the effects of head motion, we used a multivariate technique to identify both common and unique patterns of functional connectivity in the MTL vs. the dmPFC, and in vPCC vs. dPCC. All four areas had robust functional connectivity with other DMN regions, and each also showed distinct connectivity patterns in both age groups. Young and older adults had equivalent functional connectivity in the MTL subsystem. Older adults showed weaker connectivity in the vPCC and dmPFC subsystems, particularly with other DMN areas, but stronger connectivity than younger adults in the dPCC subsystem, which included areas involved in cognitive control. Our data provide evidence for distinct subsystems involving DMN nodes, which are maintained with age. Nevertheless, there are age differences in the strength of functional connectivity within these subsystems, supporting prior evidence that DMN connectivity is particularly vulnerable to age, whereas connectivity involving cognitive control regions is relatively maintained. These results suggest an age difference in the integrated activity among brain networks that can have implications for cognition in older adults.
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