ArticleSleep2013
Altered nigrostriatal and nigrocortical functional connectivity in rapid eye movement sleep behavior disorder.
Article in Sleep, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Neuropsychological Changes in Isolated REM Sleep Behavior Disorder: A Systematic Review and Meta-analysis of Cross-sectional and Longitudinal Studies.Neuropsychology review · 2024Pooled it
- Behavior- and Cell Type-Specific Cortico-Striatal Decoupling in a Parkinson's Disease-Like Mouse Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Distinct brain activation patterns linked to clinical symptoms during hand grasping in Parkinson's disease.Frontiers in aging neuroscience · 2026Article
- Functional Magnetic Resonance Imaging (fMRI) Signatures of Progression and Phenoconversion in Prodromal Synucleinopathies.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Altered Intra- and Inter-Network Resting-State Functional Connectivity is Associated with Neuropsychological Functioning and Clinical Symptoms in Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Cerebellum and basal ganglia connectivity in isolated REM sleep behaviour disorder and Parkinson's disease: an exploratory study.Brain imaging and behavior · 2024Article
- Neuroanatomical findings in isolated REM sleep behavior disorder and early Parkinson's disease: a Voxel-based morphometry study.Brain imaging and behavior · 2024Article
- Magnetic Resonance Imaging and Nuclear Imaging of Parkinsonian Disorders: Where do we go from here?Current neuropharmacology · 2024Review
- MRI brain structural and functional networks changes in Parkinson disease with REM sleep behavior disorders.Frontiers in aging neuroscience · 2024Article
- Brain MRI Biomarkers in Isolated Rapid Eye Movement Sleep Behavior Disorder: Where Are We? A Systematic Review.Brain sciences · 2023Review
- Disruption of locus coeruleus-related functional networks in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Neuropathology of incidental Lewy body & prodromal Parkinson's disease.Molecular neurodegeneration · 2023Review
- Article
- Resting-State Functional Network Topology Alterations of the Occipital Lobe Associated With Attention Impairment in Isolated Rapid Eye Movement Behavior Disorder.Frontiers in aging neuroscience · 2022Article
- Association between cigarette smoking and Parkinson's disease: a neuroimaging study.Therapeutic advances in neurological disorders · 2022Article
- Impaired Brain Information Transmission Efficiency and Flexibility in Parkinson's Disease and Rapid Eye Movement Sleep Behavior Disorder: Evidence from Functional Connectivity and Functional Dynamics.Parkinson's disease · 2022Article
- Metabolic connectivity of resting-state networks in alpha synucleinopathies, from prodromal to dementia phase.Frontiers in neuroscience · 2022Article
- Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease.Molecular medicine (Cambridge, Mass.) · 2021Review
- Limbic hypoconnectivity in idiopathic REM sleep behaviour disorder with impulse control disorders.Journal of neurology · 2021Article
- Neurochemical Features of Rem Sleep Behaviour Disorder.Journal of personalized medicine · 2021Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesRapid eye movement sleep behavior disorder (RBD) is a condition closely associated with Parkinson disease (PD). RBD is a sleep disturbance that frequently manifests early in the development of PD, likely reflecting disruption in normal functioning of anatomical areas affected by neurodegenerative processes. Although specific neuropathological aspects shared by RBD and PD have yet to be fully documented, further characterization is critical to discovering reliable biomarkers that predict PD onset. In the current study, we tested the hypothesis of altered functional connections of the substantia nigra (SN) in patients in whom RBD was diagnosed.
designBetween-groups, single time point imaging.
settingUTHSC-H 3 telsa MRI center.
participantsTen patients with RBD, 11 patients with PD, and 10 age-matched controls.
interventionsNA. MEASUREMENTS AND
resultsWe measured correlations of SN time series using resting state blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) in patients with idiopathic RBD who were at risk for developing PD, patients in whom PD was diagnosed, and age-matched controls. Using voxelwise analysis of variance, different correlations (P < 0.01, whole-brain corrected) between left SN and left putamen were found in patients with RBD compared with controls and patients with PD. SN correlations with right cuneus/precuneus and superior occipital gyrus were significantly different for patients with RBD compared with both controls and patients with PD.
conclusionsThe results suggest that altered nigrostriatal and nigrocortical connectivity characterizes rapid eye movement sleep behavior disorder before onset of obvious motor impairment. The functional changes are discussed in the context of degeneration in dopaminergic and cognition-related networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.