Evidence map›Paper›PMID 24293582›Full record

ArticleThe Journal of rheumatology2014

Does clinically important change in function after knee replacement guarantee good absolute function? The multicenter osteoarthritis study.

Jessica L Maxwell, David T Felson, Jingbo Niu, Barton Wise, Michael C Nevitt, Jasvinder A Singh, Laura Frey-Law, Tuhina Neogi

Abstract readMulticenter Study
In one paragraph

Article in The Journal of rheumatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Challenging the neutral axis: 15-year results of under-corrected varus in total knee arthroplasty.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Individual patient monitoring in daily clinical practice: a critical evaluation of minimal important change.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jessica L MaxwellFrom the Department of Physical Therapy and Athletic Training, College of Health and Rehabilitation Sciences, Boston University; Clinical Epidemiology Training Unit, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
David T Felson
Jingbo Niu
Barton Wise
Michael C Nevitt
Jasvinder A Singh
Laura Frey-Law
Tuhina Neogi

Funding

Multicenter Osteoarthritis Study (MOST) Second RenewalU01AG019069 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL C · 2001 to 2020
$21.7M
WORK DISABILITY-- PERSONS WITH RHEUMATOID ARTHRITISP60AR047785 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2016
$18.0M
Multicenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical CenterU01AG018832 · NIA · UNIVERSITY OF IOWA · PI SEGAL, NEIL A, TORNER, JAMES C · 2001 to 2020
$14.1M
Multicenter Osteoarthritis Study (MOST) Second Renewal - Boston UniversityU01AG018820 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2019
$13.6M
Multicenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical CenterU01AG018947 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 2001 to 2020
$13.2M
Building Interdisciplinary Research Careers in Womens Health at UC Davis - Administrative SupplementK12HD051958 · NICHD · UNIVERSITY OF CALIFORNIA DAVIS · PI LANE, NANCY E · 2005 to 2023
$9.6M
Central Sensitization in Post-Knee Replacement Pain and Relation to OA PathologyR01AR062506 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NEOGI, TUHINA · 2012 to 2016
$2.4M
Predictors and Consequences of Subchondral Bone Attrition in OsteoarthritisK23AR055127 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NEOGI, TUHINA · 2007 to 2011
$631k
NIAMS NIH HHS AR-47785NIAMS NIH HHS K23 AR055127NIAMS NIH HHS P60 AR047785NIAMS NIH HHS R01 AR062506NIA NIH HHS U01 AG018820NIA NIH HHS U01 AG018832NIA NIH HHS U01 AG018947NIA NIH HHS U01 AG019069NIA NIH HHS U01-AG18820NIA NIH HHS U01-AG18832NIA NIH HHS U01-AG18947NIA NIH HHS U01-AG19069NICHD NIH HHS K12 HD051958PHS HHS H133B100003-11
6 · The paper itself

Abstract

objectivePoor functional outcomes post-knee replacement are common, but estimates of its prevalence vary, likely in part because of differences in methods used to assess function. The agreement between improvement in function and absolute good levels of function after knee replacement has not been evaluated. We evaluated the attainment of improvement in function and absolute good function after total knee replacement (TKR) and the agreement between these measures.

methodsUsing data from The Multicenter Osteoarthritis (MOST) Study, we determined the prevalence of achieving a minimal clinically important improvement (MCII, ≥ 14.2/68 point improvement) and Patient Acceptable Symptom State (PASS, ≤ 22/68 post-TKR score) on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Physical Function subscale at least 6 months after knee replacement. We also assessed the frequency of co-occurrence of the 2 outcomes, and the prevalence according to pre-knee replacement functional status.

resultsWe included 228 subjects who had a knee replacement during followup (mean age 65 yrs, mean body mass index 33.4, 73% female). Seventy-one percent attained the PASS for function after knee replacement, while only 44% attained the MCII. Of the subjects who met the MCII, 93% also attained the PASS; however, of subjects who did not meet the MCII, 54% still achieved a PASS. Baseline functional status was associated with attainment of each MCII and PASS.

conclusionThere was only partial overlap between attainment of a good level of function and actually improving by an acceptable amount. Subjects were more likely to attain an acceptable level of function than to achieve a clinically important amount of improvement post-knee replacement.

Indexed as

Arthroplasty, Replacement, KneeAgedFemaleHumansMaleMiddle AgedOsteoarthritis, KneePain MeasurementPatient SatisfactionRecovery of FunctionSeverity of Illness IndexTreatment OutcomeKNEE REPLACEMENTOUTCOMESPHYSICAL FUNCTION

Identifiers

PMID24293582
PMCPMC3914207

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.