ArticleThe Journal of rheumatology2014
Associations of smoking and alcohol consumption with disease activity and functional status in rheumatoid arthritis.
Article in The Journal of rheumatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Pooled it
- The association between alcohol consumption and osteoarthritis: a meta-analysis and meta-regression of observational studies.Rheumatology international · 2021Pooled it
- Exploring the effect of alcohol on disease activity and outcomes in rheumatoid arthritis through systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Smoking quantity determines disease activity and function in Chinese patients with ankylosing spondylitis.Clinical rheumatology · 2018Pooled it
- The Effect of Tobacco Smoking on Musculoskeletal Health: A Systematic Review.Journal of environmental and public health · 2018Pooled it
- Changes in cardiovascular risk factors in patients with inflammatory arthritis following screening consultations-a Danish register-based cohort study.EULAR rheumatology open · 2026Article
- Cigarette smoking habits and attitudes among rheumatoid arthritis patients at a tertiary centre in South Africa.Journal of the colleges of medicine of South Africa · 2026Article
- The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive Review.Nutrients · 2025Review
- Functional disability and disease activity are affected by social determinants of health in patients with rheumatoid arthritis.Clinical rheumatology · 2024Article
- The relationship between physical performance and alcohol consumption levels in Russian adults.Scientific reports · 2024Article
- Article
- The association between disease duration and mood disorders in rheumatoid arthritis patients.Clinical rheumatology · 2022Article
- Lifestyle factors in patients with rheumatoid arthritis-a cross-sectional study on two Scandinavian cohorts.Clinical rheumatology · 2022Article
- Prevalence and Risk Factors of Substance Use Disorder in Rheumatoid Arthritis.ACR open rheumatology · 2021Article
- Alcohol Consumption and Risk of Rheumatoid Arthritis among Chinese Adults: A Prospective Study.Nutrients · 2021Article
- [Depression and anxiety in patients with psoriatic arthritis: Prevalence and associated factors].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020Article
- The effect of smoking on disease activity in rheumatoid arthritis - our experience.Acta clinica Croatica · 2020Article
- Modifiable Lifestyle Factors Associated With Response to Treatment in Early Rheumatoid Arthritis.ACR open rheumatology · 2020Article
- Dietary Habits and Nutrition in Rheumatoid Arthritis: Can Diet Influence Disease Development and Clinical Manifestations?Nutrients · 2020Review
- Changes in Alcohol Use and Associations With Disease Activity, Health Status, and Mortality in Rheumatoid Arthritis.Arthritis care & research · 2020Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveTo investigate the associations of smoking and alcohol consumption with disease activity and functional status in rheumatoid arthritis (RA).
methodsWe conducted a prospective study consisting of 662 patients with RA who were followed up to 7 years from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study. Smoking and alcohol consumption were assessed through yearly questionnaires. The disease activity and functional status were measured annually by the Disease Activity Score examined in 28 commonly affected joints using C-reactive protein (DAS28-CRP3) and the Modified Health Assessment Questionnaire (MHAQ). Linear mixed models were developed to assess the longitudinal effects of smoking and alcohol consumption on DAS28-CRP3 and MHAQ after adjustment for potential confounders. The HLA-DRB1 shared epitope (HLA-SE) by smoking and alcohol interactions were also evaluated in the analysis.
resultsThe median followup time of the cohort was 4 years. Current smoking was not associated with DAS28-CRP3 in our study, but was associated with a higher MHAQ than nonsmokers with seropositive RA (p = 0.05). Alcohol consumption showed an approximate J-shaped relationship with MHAQ, with the minima occurring at 5.1-10.0 g/day. Compared to no alcohol use, alcohol consumption of 5.1-10.0 g/day was associated with a significant decrease of MHAQ (p = 0.02). When stratified by HLA-SE, the effect of alcohol consumption appeared to be stronger in HLA-SE-positive RA than HLA-SE-negative RA.
conclusionWe found that current smoking was associated with a worse functional status, while moderate alcohol consumption was associated with a better functional status in RA. Replications of these findings in other prospective studies are needed.
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