ArticleCerebral cortex (New York, N.Y. : 1991)2015
Cognitive abilities on transitive inference using a novel touchscreen technology for mice.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- A novel rat spatial inference task reveals rapid deduction of transitive relationships using schemas and deliberation.Behavioral neuroscience · 2026Article
- Percentile schedules to shape touchscreen response locations in cynomolgus macaques.Journal of the experimental analysis of behavior · 2026Article
- Cost-effective, open-source, automated apparatus for testing transitive inference in mice.Scientific reports · 2026Article
- A Novel Rat Spatial Inference Task Reveals Rapid Deduction of Transitive Relationships Using Schemas and Deliberation.bioRxiv : the preprint server for biology · 2025Article
- Review
- Bridging the translational gap: what can synaptopathies tell us about autism?Frontiers in molecular neuroscience · 2023Review
- In the absence of extensive initial training, cleaner wrasse Labroides dimidiatus fail a transitive inference task.PloS one · 2023Article
- Reduced exploratory behavior in neuronal nucleoredoxin knockout mice.Redox biology · 2021Article
- Chemogenetic suppression of anterior cingulate cortical neurons projecting to the visual cortex disrupts attentional behavior in mice.Neuropsychopharmacology reports · 2021Article
- Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2.Cellular and molecular life sciences : CMLS · 2021Article
- Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice.Nature communications · 2020Article
- Mutations in neuroligin-3 in male mice impact behavioral flexibility but not relational memory in a touchscreen test of visual transitive inference.Molecular autism · 2019Article
- Touchscreen learning deficits in Ube3a, Ts65Dn and Mecp2 mouse models of neurodevelopmental disorders with intellectual disabilities.Genes, brain, and behavior · 2018Article
- Enhanced Operant Extinction and Prefrontal Excitability in a Mouse Model of Angelman Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Inferential Learning of Serial Order of Perceptual Categories by Rhesus Monkeys (The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Touchscreen learning deficits and normal social approach behavior in the Shank3B model of Phelan-McDermid Syndrome and autism.Neuroscience · 2017Article
- 5HTGenes, brain, and behavior · 2017Article
- Using Animal Models to Study the Role of the Gut-Brain Axis in Autism.Current developmental disorders reports · 2017Review
- The importance of the altricial - precocial spectrum for social complexity in mammals and birds - a review.Frontiers in zoology · 2017Review
- Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive abilities are impaired in neurodevelopmental disorders, including autism spectrum disorder (ASD) and schizophrenia. Preclinical models with strong endophenotypes relevant to cognitive dysfunctions offer a valuable resource for therapeutic development. However, improved assays to test higher order cognition are needed. We employed touchscreen technology to design a complex transitive inference (TI) assay that requires cognitive flexibility and relational learning. C57BL/6J (B6) mice with good cognitive skills and BTBR T+tf/J (BTBR), a model of ASD with cognitive deficits, were evaluated in simple and complex touchscreen assays. Both B6 and BTBR acquired visual discrimination and reversal. BTBR displayed deficits on components of TI, when 4 stimuli pairs were interspersed, which required flexible integrated knowledge. BTBR displayed impairment on the A > E inference, analogous to the A > E deficit in ASD. B6 and BTBR mice both reached criterion on the B > D comparison, unlike the B > D impairment in schizophrenia. These results demonstrate that mice are capable of complex discriminations and higher order tasks using methods and equipment paralleling those used in humans. Our discovery that a mouse model of ASD displays a TI deficit similar to humans with ASD supports the use of the touchscreen technology for complex cognitive tasks in mouse models of neurodevelopmental disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.