ArticleInsights into imaging2014
Atypical ultrasound features of parathyroid tumours may bear a relationship to their clinical and biochemical presentation.
Article in Insights into imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Essentials for parathyroid imaging and intervention: what radiologists need to know.Ultrasonography (Seoul, Korea) · 2025Article
- Lesion size and cystic morphology are key determinants of parathyroid hormone washout in primary hyperparathyroidism.Frontiers in endocrinology · 2025Article
- Multi-modality parathyroid imaging: A shifting paradigm.World journal of radiology · 2023Review
- Overview of the 2022 WHO Classification of Parathyroid Tumors.Endocrine pathology · 2022Review
- Primary hyperparathyroidism-related giant parathyroid adenoma (Review).Experimental and therapeutic medicine · 2022Review
- Multiple parathyroid adenomas with variable ultrasonography and computed tomography findings in a patient with chronic kidney disease: A case report.Radiology case reports · 2020Article
- Multimodality Imaging in Patients with Secondary Hypertension: With a Focus on Appropriate Imaging Approaches Depending on the Etiologies.Korean journal of radiologyArticle
- Evaluation of preoperative ultrasonographic and biochemical features of patients with aggressive parathyroid disease: is there a reliable predictive marker?Archives of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo describe atypical ultrasound features of parathyroid lesions and correlate them with clinical presentation and histopathology. MATERIALS AND
methodsRetrospective review of 264 patients with primary hyperparathyroidism who underwent ultrasound imaging prior to parathyroidectomy was performed. Patients with atypical ultrasound findings (n = 26) were identified; imaging findings were correlated with clinical presentation and histopathology.
resultsTwenty-one (80 %) lesions were adenomas, two (8 %) were adenomas with cellular atypia, and three (11.5 %) were carcinomas. Seventeen (65 %) lesions showed cystic change; five (19 %) of them had >50 % cystic change. These lesions were adenomas with cystic degeneration. Cystic degeneration had significant positive correlation with the lesion size and PTH level, but cystic adenomas correlated negatively with lesion weight. Six (23 %) lesions were isoechoic and one (4 %) was hyperechoic; histology predominantly revealed haemorrhage, hyalinisation and fibrosis; one lesion showed fat deposition and another had multiple granulomas within the adenoma. Twenty (83 %) lesions had heterogeneous echotexture and showed combinations of acinar dilatation, necrosis, haemorrhage and fibrosis. Heterogeneous lesions tended to be significantly larger and heavier, and they were associated with higher PTH levels. Four (15 %) lesions had calcifications. Scintigraphy was concordant in 22 (96 %), n = 23. One scintigraphy-negative lesion was a cystic parathyroid adenoma.
conclusionAtypical ultrasound features of parathyroid lesions pose a diagnostic challenge. Awareness of these features would help improve lesion detection. TEACHING POINTS: 1. Cystic change is significantly related to the size, weight and measured parathyroid hormone levels. 2. Cystic change in parathyroid tumours indicated a slightly higher risk of malignancy. 3. Heterogeneous parathyroid adenomas are larger in size and heavier, and they have higher PTH levels. 4. Awareness of atypical ultrasound features will improve preoperative clinical prediction.
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Registered trials
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