SynthesisQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2014
Meta-analysis shows clinically relevant and long-lasting deterioration in health-related quality of life after esophageal cancer surgery.
Synthesis in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A meta-analytic review of religious or spiritual involvement and social health among cancer patients.Cancer · 2015Pooled it
- Quality of life and dietary changes among cancer patients: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Pooled it
- Pooled it
- The impact of ERAS-based nursing interventions on postoperative complication management and prognosis in early gastrointestinal tumor endoscopic resection: a prospective randomized controlled study.Langenbeck's archives of surgery · 2025Trial
- QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Trial
- Neoadjuvant cisplatin and fluorouracil versus epirubicin, cisplatin, and capecitabine followed by resection in patients with oesophageal adenocarcinoma (UK MRC OE05): an open-label, randomised phase 3 trial.The Lancet. Oncology · 2017Trial
- Physical ExeRcise Following Esophageal Cancer Treatment (PERFECT) study: design of a randomized controlled trial.BMC cancer · 2017Trial
- Patient-reported outcomes during and after definitive chemoradiotherapy for oesophageal cancer.British journal of cancer · 2015Trial
- Article
- Health-related quality of life 15 years after oesophageal cancer surgery: a prospective nationwide cohort study.Journal of cancer survivorship : research and practice · 2023Article
- Cancer-Related Fatigue After Esophageal Cancer Surgery: Impact of Postoperative Complications.Annals of surgical oncology · 2022Article
- Health-related quality of life after esophagectomy in patients with esophageal cancer.Esophagus : official journal of the Japan Esophageal Society · 2022Review
- Severe reflux, sleep disturbances, and health-related quality of life after esophageal cancer surgery.Journal of cancer survivorship : research and practice · 2021Article
- Functional syndromes and symptom-orientated aftercare after esophagectomy.Langenbeck's archives of surgery · 2021Review
- Outcomes of single versus two stage oesophagectomy for squamous cell carcinoma.EClinicalMedicine · 2020Article
- Development and Feasibility of a Mobile Health-Supported Comprehensive Intervention Model (CIMmH) for Improving the Quality of Life of Patients With Esophageal Cancer After Esophagectomy: Prospective, Single-Arm, Nonrandomized Pilot Study.Journal of medical Internet research · 2020Article
- Preliminary Normative Standards of the Mayo Clinic Esophagectomy CONDUIT Tool.Mayo Clinic proceedings. Innovations, quality & outcomes · 2019Article
- Population-based study of anastomotic stricture rates after minimally invasive and open oesophagectomy for cancer.BJS open · 2019Article
- Psychological support of esophageal cancer patient?Journal of thoracic disease · 2019Review
- Health-related quality of life after gastrectomy, esophagectomy, and combined esophagogastrectomy for gastroesophageal junction adenocarcinoma.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
purposeThe purpose of the study is to (1) estimate the direction, clinical relevance, and duration of health-related quality-of-life (HRQL) change in the first year following esophageal cancer surgery and (2) to assess the robustness of the estimates by subgroup and sensitivity analyses, and an exploration of publication bias.
methodsA systematic literature search in MEDLINE, EMBASE, CINAHL, PsychINFO, and CENTRAL to identify randomized and non-randomized studies was performed. We compared the baseline HRQL data with 3-, 6-, 9-, or 12-month follow-ups to estimate the magnitude and duration of HRQL change. These estimates were then classified as trivial, small, medium, or large. Primary outcomes were role functioning, eating, and fatigue. Secondary outcomes were physical and social functioning, dysphagia, pain, and coughing problems. We conducted subgroup analysis for open surgery, open surgery preceded by neoadjuvant therapy, and minimally invasive surgery. Sensitivity analyses assessed the influence of study design, transformation/imputation of the data, and HRQL questionnaire used.
resultsWe included the data from 15 studies to estimate the change in 28 HRQL outcomes after esophageal cancer surgery. The main analysis showed that patients' social functioning deteriorated. Symptoms of fatigue, pain, and coughing problems increased. These changes lasted for 9-12 months, although some symptoms persisted beyond the first year after surgery. For many other HRQL outcomes, estimates were only robust after subgroup or sensitivity analyses (e.g., role and physical functioning), or remained too heterogeneous to interpret (e.g., eating and dysphagia).
conclusionsPatients will experience a clinically relevant and long-lasting deterioration in HRQL after esophageal cancer surgery. However, for many HRQL outcomes, more and better quality evidence is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.