Evidence map›Paper›PMID 24292970›Full record

ReviewCurrent diabetes reports2014

Glucose control during labor and delivery.

Edmond A Ryan, Rany Al-Agha

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Current diabetes reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02590016 phase4unknown statusnot on this mapstarted 2015, after this paper: background citation

Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: Insulin-Glucose-Infusion Versus Observational Approach - Is There a Difference in Neonatal Hypoglycemia Rate?

TypeinterventionalSponsorTampere University HospitalRan2015 to 2021Enrolled50ConditionsGestational Diabetes, Hypoglycemia, NeonatalArmsInsulin, Aspart
NCT07420972 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Pilot Study of Intrapartum Insulin Pump Use: Feasibility, Efficacy and Safety

TypeinterventionalSponsorMedstar Health Research InstituteRan2026 to 2028Enrolled30ConditionsDiabetes, Diabetes (Insulin-requiring, Type 1 or Type 2), PregnancyArmsInsulin pump
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Intrapartum Glycemic Control and Clinical Outcomes.Diabetes spectrum : a publication of the American Diabetes Association · 2025
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Edmond A RyanDivision of Endocrinology and Metabolism and Alberta Diabetes Institute, 362 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, T6G 2S2, Canada, edmond.ryan@ualberta.ca.
Rany Al-Agha
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal hypoglycemia is an important consequence for the infant of the mother with diabetes. We have reviewed 24 published papers of various protocols for control of glucose in pregnant diabetic women during labor and delivery including our own published work. A relationship of maternal glucose during labor and neonatal hypoglycemia was sought in 19 of these studies. A significant inverse relationship was found in 10 reports with 3 others showing a similar trend. In all but 1 of these 13 studies the participants had pregestational diabetes. Three of the 6 studies not reporting an inverse relationship involved women with GDM. From this review it appears that the maternal glucose should be maintained between 4.0 and 6.0-7.0 mmol/L during labor. Most women with gestational diabetes, especially if they require <1.0 units/kg/d of insulin, can simply be monitored without intravenous insulin. Our own results demonstrate that a target glucose of 4.0-6.0 mmol/L can be used safely and results in a low rate of neonatal hypoglycemia using an iterative glucose insulin infusion protocol for women with pregestational diabetes and when needed for women with gestational diabetes.

Indexed as

Delivery, ObstetricLabor, ObstetricBlood GlucoseDiabetes, GestationalFemaleHumansInsulinPregnancyBlood GlucoseInsulin

Identifiers

PMID24292970
OpenAlexW2055313987

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.