Evidence map›Paper›PMID 24292903›Full record

ArticleAdvances in physiology education2013

Pattern recognition receptors in innate immunity, host defense, and immunopathology.

Rahul Suresh, David M Mosser

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in physiology education, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 216 citations in OpenAlex.

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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rahul SureshDepartment of Cell Biology and Molecular Genetics and the Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland.
David M Mosser
University of Maryland, College Park · US

Funding

Regulatory macrophages and the host inflammatory responseR01GM102589 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI MOSSER, DAVID M · 2013 to 2016
$1.2M
NIGMS NIH HHS R01 GM102589
6 · The paper itself

Abstract

Infection by pathogenic microbes initiates a set of complex interactions between the pathogen and the host mediated by pattern recognition receptors. Innate immune responses play direct roles in host defense during the early stages of infection, and they also exert a profound influence on the generation of the adaptive immune responses that ensue. An improved understanding of the pattern recognition receptors that mediate innate responses and their downstream effects after receptor ligation has the potential to lead to new ways to improve vaccines and prevent autoimmunity. This review focuses on the control of innate immune activation and the role that innate immune receptors play in helping to maintain tissue homeostasis.

Indexed as

Immunity, InnateAdjuvants, ImmunologicAnimalsHumansReceptors, Pattern RecognitionToll-Like ReceptorsVaccinesAdjuvants, ImmunologicReceptors, Pattern RecognitionToll-Like ReceptorsVaccinesantigen presentationchemokinesdamage-associated molecular patternspathogen-associated molecular patternspattern recognition receptorsToll-like receptorsvaccines

Identifiers

PMID24292903
PMCPMC4089092
OpenAlexW2163565143

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.