Evidence map›Paper›PMID 24292820›Full record

SynthesisEuropean journal of nutrition2014

Vitamin D supplementation, body weight and human serum 25-hydroxyvitamin D response: a systematic review.

Armin Zittermann, Jana B Ernst, Jan F Gummert, Jochen Börgermann

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Effect of epigenetics on vitamin D levels: a systematic review until December 2020.Archives of public health = Archives belges de sante publique · 2023
    Pooled it
  4. Vitamin D supplementation for chronic liver diseases in adults.The Cochrane database of systematic reviews · 2021
    Pooled it
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  9. Vitamin D supplementation for chronic liver diseases in adults.The Cochrane database of systematic reviews · 2017
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  12. Vitamins DFrontiers in immunology · 2022
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Armin ZittermannClinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Centre North Rhine-Westphalia (NRW), Ruhr University Bochum, Georgstr. 11, 32545, Bad Oeynhausen, Germany, azittermann@hdz-nrw.de.
Jana B Ernst
Jan F Gummert
Jochen Börgermann

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere is considerable variation in incremental circulating 25-hydroxyvitamin D (25OHD) levels on vitamin D supplements, even when similar age groups and identical vitamin D doses are compared. We therefore aimed to investigate the importance of body weight for the dose-response relation in circulating 25OHD.

methodsWe performed a systematic review of randomized placebo-controlled vitamin D supplementation trials in all age groups ≥10 years to clarify the influence of body weight and other parameters on incremental circulating 25OHD levels (difference between baseline and in-study values) in vitamin D-deficient and non-deficient individuals.

resultsWe included 144 cohorts from 94 independent studies, published from 1990 to November 2012, in our systematic review. There was a logarithmic association between vitamin D dose per kg body weight per day and increment in circulating 25OHD. In multivariable regression analysis, vitamin D dose per kg body weight per day could explain 34.5% of variation in circulating 25OHD. Additional significant predictors were type of supplement (vitamin D2 or vitamin D3), age, concomitant intake of calcium supplements and baseline 25OHD, explaining 9.8, 3.7, 2.4 and 1.9%, respectively, of the variation in circulating 25OHD.

conclusionsThis systematic review demonstrates that body weight is an important predictor of variation in circulating 25OHD in cohorts on vitamin D supplements. Our model provides an estimate of the daily vitamin D dose that is necessary for achieving adequate circulating 25OHD levels in vitamin D-insufficient or vitamin D-deficient individuals/cohorts with different body weights and ages.

Indexed as

Body WeightAdolescentAdultAgedAged, 80 and overAge FactorsCalciumChildCholecalciferolDietary SupplementsErgocalciferolsFemaleHumansMaleMiddle AgedVitamin D25-hydroxyvitamin DCalciumCholecalciferolErgocalciferolsVitamin D

Identifiers

PMID24292820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.