Observational studyEuropean journal of nutrition2014
Iron deficiency and anemia in iron-fortified formula and human milk-fed preterm infants until 6 months post-term.
Observational study in European journal of nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Iron supplementation in preterm and low-birth-weight infants: a systematic review of intervention studies.Nutrition reviews · 2019Pooled it
- The Effect of the Combination of Probiotics and Heavy Metals From Various Aspects in Humans: A Systematic Review of Clinical Trial Studies.Health science reports · 2025Review
- Growth and micronutrient status parameters of Nigerian preterm infants consuming preterm formula or breastmilk.Pediatric research · 2024Observational
- Article
- Iron Supplementation Influence on the Gut Microbiota and Probiotic Intake Effect in Iron Deficiency-A Literature-Based Review.Nutrients · 2020Review
- A Retrospective Case-Control Study of the Determinants of Iron Deficiency Anemia in Infants in an Urban Community in Shanghai, China Between 2010-2015.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- [Research advances in the relationship between iron deficiency and neurodevelopment in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018Article
- Longitudinal Effects of Iron Deficiency Anemia and Subsequent Repletion on Blood Parameters and the Rate and Composition of Growth in Pigs.Nutrients · 2018Article
- Predictive factors of iron depletion in late preterm infants at the postnatal age of 6 weeks.European journal of clinical nutrition · 2016Article
- Postdischarge Iron Requirements of the Preterm Infant.The Journal of pediatrics · 2015Review
- Iron deficiency in the first 6 months of age in infants born between 32 and 37 weeks of gestational age.European journal of clinical nutrition · 2015Article
- Identification, prevention and treatment of iron deficiency during the first 1000 days.Nutrients · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAn iron intake of >2 mg/kg/d is recommended for preterm infants. We hypothesized that human milk (HM)-fed preterm infants require iron supplementation after discharge, whereas iron-fortified formulae (IFF; 0.8-1.0 mg iron/100 ml) may provide sufficient dietary iron until 6 months post-term.
methodsAt term age, 3 and 6 months post-term, ferritin (μg/l) was measured in 92 IFF-fed infants (gestational age (median (interquartile range)) 30.7 (1.4) weeks, birth weight 1,375 (338) gram) and 46 HM-fed infants (gestational age 30.0 (1.7) weeks, birth weight 1,400 (571) gram). Iron intake (mg/kg/d) between term age and 6 months post-term was calculated.
resultsIron was supplemented to 71.7% of HM-fed and 83.7% of IFF-fed infants between term age and 3 months post-term and to 13% of HM-fed and 0% of IFF-fed infants between 3 and 6 months post-term. IFF-fed infants had an iron intake from supplements and formula of 2.66 (1.22) mg/kg/d between term age and 3 months post-term and 1.19 (0.32) mg/kg/d between 3 and 6 months post-term. At 3 and 6 months post-term, the incidence of ferritin <12 μg/l was higher in HM-fed compared to IFF-fed infants (23.8 vs. 7.8% and 26.3 vs. 9.5%, P < 0.02).
conclusionThis observational study demonstrates that ferritin <12 μg/l is more prevalent in HM-fed infants until 6 months post-term. This may be due to early cessation of additional iron supplementation. We speculate that additional iron supplementation is not necessary in preterm infants fed IFF (0.8-1.0 mg iron/100 ml), as they achieve ferritin ≥12 μg/l without additional iron supplements between 3 and 6 months post-term.
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