ArticleNature structural & molecular biology2014
Energetic analysis of the rhodopsin-G-protein complex links the α5 helix to GDP release.
Article in Nature structural & molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Ligand-dependent G protein dynamics underlying opioid efficacy.Nature structural & molecular biology · 2026Article
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- Ligand-dependent G protein dynamics underlying opioid signaling efficacy.bioRxiv : the preprint server for biology · 2025Article
- The role of G protein conformation in receptor-G protein selectivity.Nature chemical biology · 2023Article
- Structure and function of the metagenomic plastic-degrading polyester hydrolase PHL7 bound to its product.Nature communications · 2023Article
- Low Carbon Footprint Recycling of Post-Consumer PET Plastic with a Metagenomic Polyester Hydrolase.ChemSusChem · 2022Article
- Internal water channel formation in CXCR4 is crucial for GCommunications chemistry · 2020Article
- Rosetta Machine Learning Models Accurately Classify Positional Effects of Thioamides on Proteolysis.The journal of physical chemistry. B · 2020Article
- Rapid Simulation of Unprocessed DEER Decay Data for Protein Fold Prediction.Biophysical journal · 2020Article
- Assembly of a GPCR-G Protein Complex.Cell · 2019Article
- A New Multisystem Disorder Caused by the Gαs Mutation p.F376V.The Journal of clinical endocrinology and metabolism · 2019Article
- Recent advances in computational studies of GPCR-G protein interactions.Advances in protein chemistry and structural biology · 2019Review
- Comparative structural dynamic analysis of GTPases.PLoS computational biology · 2018Article
- Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa.BMC evolutionary biology · 2018Article
- Integrated Structural Biology for α-Helical Membrane Protein Structure Determination.Structure (London, England : 1993) · 2018Article
- Active Site Flexibility as a Hallmark for Efficient PET Degradation by I. sakaiensis PETase.Biophysical journal · 2018Article
- Structure and dynamics of GPCR signaling complexes.Nature structural & molecular biology · 2018Review
- Molecular Mechanisms of GPCR Signaling: A Structural Perspective.International journal of molecular sciences · 2017Review
- Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.Nature communications · 2017Article
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6 authors.
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Abstract
We present a model of interaction of Gi protein with the activated receptor (R*) rhodopsin, which pinpoints energetic contributions to activation and reconciles the β2 adrenergic receptor-Gs crystal structure with new and previously published experimental data. In silico analysis demonstrated energetic changes when the Gα C-terminal helix (α5) interacts with the R* cytoplasmic pocket, thus leading to displacement of the helical domain and GDP release. The model features a less dramatic domain opening compared with the crystal structure. The α5 helix undergoes a 63° rotation, accompanied by a 5.7-Å translation, that reorganizes interfaces between α5 and α1 helices and between α5 and β6-α5. Changes in the β6-α5 loop displace αG. All of these movements lead to opening of the GDP-binding pocket. The model creates a roadmap for experimental studies of receptor-mediated G-protein activation.
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