ArticleEuropean child & adolescent psychiatry2014
BDNF genetic variability modulates psychopathological symptoms in patients with eating disorders.
Article in European child & adolescent psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of COMT, BDNF and 5-HTT brain-genes on the development of anorexia nervosa: a systematic review.Eating and weight disorders : EWD · 2021Pooled it
- Comprehensive insights into emerging advances in the Neurobiology of anorexia.Journal of advanced research · 2026Review
- Association ofJournal of clinical medicine · 2024Article
- Review
- Relationship of Genetic Polymorphisms and Microbial Composition with Binge Eating Disorder: A Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
- Inclusion of the severe and enduring anorexia nervosa phenotype in genetics research: a scoping review.Journal of eating disorders · 2024Article
- Variability in cannabinoid receptor genes is associated with psychiatric comorbidities in anorexia nervosa.Eating and weight disorders : EWD · 2021Article
- Genotype-expression interactions for BDNF across human brain regions.BMC genomics · 2021Article
- Genetic variants in dopamine pathways affect personality dimensions displayed by patients with eating disorders.Eating and weight disorders : EWD · 2021Article
- Influence ofBrain and behavior · 2017Article
- TOX and ADIPOQ Gene Polymorphisms Are Associated with Antipsychotic-Induced Weight Gain in Han Chinese.Scientific reports · 2017Article
- Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.Molecular psychiatry · 2017Article
- Association between obesity and the brain-derived neurotrophic factor gene polymorphism Val66Met in individuals with bipolar disorder in Mexican population.Neuropsychiatric disease and treatment · 2016Article
- Impact of NEGR1 genetic variability on psychological traits of patients with eating disorders.The pharmacogenomics journal · 2015Article
- Identification of determinants of referral and follow-up body mass index of adolescent patients with anorexia nervosa: evidence for the role of premorbid body weight.European child & adolescent psychiatry · 2015Article
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Authors and funding
9 authors.
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Abstract
The brain-derived neurotrophic factor (BDNF) gene may influence eating behavior, body weight and cognitive impairments. We aimed to investigate whether BDNF genetic variability may affect anthropometric and psychological parameters in patients with anorexia or bulimia nervosa (AN, BN) and/or modulate the risk for the disorder. A total of 169 unrelated female patients and 312 healthy controls were genotyped for two common BDNF single-nucleotide polymorphisms (SNPs), Val66Met and C-270T, and several selected tag-SNPs. Associated personality characteristics and psychopathological symptoms were assessed by the EDI-2 and SCL-90R inventories, respectively. No single SNP or haplotype played a relevant role in the risk for AN or BN. The rs16917237 TT genotype was significantly associated with increased weight (74.63 ± 16.58 vs. 57.93 ± 13.02) and body mass index (28.94 ± 6.22 vs. 22.23 ± 4.77) in the BN group after correcting for multiple testing. Haplotype analyses using a sliding window approach with three adjacent SNPs produced four loci of interest. Locus 3 (rs10835210/rs16917237/C-270T) showed a broad impact on the measured psychopathological symptoms. Haplotypes CGC and CGT in this locus correlated with scores in all three scales of the SCL-90R inventory, both in AN and BN patients. In contrast, the results of the EDI-2 inventory were largely unaffected. These preliminary results suggest that variability in the BDNF gene locus may contribute to anthropometric characteristics and also psychopathological symptoms that are common but not exclusive of ED patients.
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