Evidence map›Paper›PMID 24292274›Full record

SynthesisNature genetics2014

A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.

Helen E Speedy, Maria Chiara Di Bernardo, Georgina P Sava, Martin J S Dyer, Amy Holroyd, Yufei Wang, Nicola J Sunter, Larry Mansouri, Gunnar Juliusson, Karin E Smedby and 19 more

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  6. TERT rs10069690 polymorphism and cancers risk: A meta-analysis.Molecular genetics & genomic medicine · 2019
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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Helen E Speedy1] Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK. [2].
Maria Chiara Di Bernardo1] Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK. [2].
Georgina P SavaDivision of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK.
Martin J S DyerDepartment of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK.
Amy HolroydDivision of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK.
Yufei WangDivision of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK.
Nicola J SunterNorthern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK.
Larry MansouriDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Gunnar JuliussonLund Strategic Research Center for Stem Cell Biology and Cell Therapy, Hematology and Transplantation, Lund University, Lund, Sweden.
Karin E SmedbyUnit of Clinical Epidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Göran RoosDepartment of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
Sandrine JayneMedical Research Council Toxicology Unit, Leicester University, Leicester, UK.
Aneela MajidMedical Research Council Toxicology Unit, Leicester University, Leicester, UK.
Claire DeardenHaemato-Oncology, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, UK.
Andrew G HallNorthern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK.
Tryfonia Mainou-FowlerHaematological Sciences, Medical School, Newcastle University, Newcastle-upon-Tyne, UK.
Graham H JacksonDepartment of Haematology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK.
Geoffrey SummerfieldDepartment of Haematology, Queen Elizabeth Hospital, Gateshead, Newcastle-upon-Tyne, UK.
Robert J HarrisDepartment of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.
Andrew R PettittDepartment of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.
David J AllsupDepartment of Haematology, Hull Royal Infirmary, Hull, UK.
James R BaileyHull York Medical School and University of Hull, Hull, UK.
Guy PrattDepartment of Haematology, Birmingham Heartlands Hospital, Birmingham, UK.
Chris PepperDepartment of Haematology, School of Medicine, Cardiff University, Cardiff, UK.
Chris FeganCardiff and Vale National Health Service Trust, Heath Park, Cardiff, UK.
Richard RosenquistDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Daniel CatovskyHaemato-Oncology, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, UK.
James M AllanNorthern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK.
Richard S HoulstonDivision of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK.

Funding

Cancer Research UK 15116Cancer Research UK 18779Cancer Research UK C1298/A8362Wellcome Trust
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10(-9)), 4q26 (rs6858698, P = 3.07 × 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 × 10(-7)) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 × 10(-10)) and 8q22.3 (rs2511714, P = 2.90 × 10(-9)). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL.

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyPolymorphism, Single NucleotideAgedCase-Control StudiesChromosomes, Human, Pair 3HumansLeukemia, Lymphocytic, Chronic, B-CellMaleMembrane ProteinsMiddle AgedNeoplasm ProteinsRecombination, GeneticShelterin ComplexTelomere-Binding ProteinsCLPTM1L protein, humanMembrane ProteinsNeoplasm ProteinsPOT1 protein, humanShelterin ComplexTelomere-Binding Proteins

Identifiers

PMID24292274

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.