ArticleNature neuroscience2014
Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory.
Article in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
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- Reduction of tumor necrosis factor (TNF) in milk of women receiving anti-TNF antibody.Pediatric research · 2025Observational
- The importance of investigating the effects of drug therapy on maternal breast milk composition.Pediatric research · 2025Article
- Association between serum chemokines levels and delayed neurocognitive recovery after non-cardiac surgery in elderly patients: a nested case-control study.Perioperative medicine (London, England) · 2025Article
- Preeclampsia promotes autism in offspring via maternal inflammation and fetal NFκB signaling.Life science alliance · 2023Article
- Complex Neuroimmune Involvement in Neurodevelopment: A Mini-Review.Journal of inflammation research · 2023Review
- Chronic cerebral aspects of long COVID, post-stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic.Pharmacology research & perspectives · 2022Review
- Early Life Exposure to Tumor Necrosis Factor Induces Precocious Sensorimotor Reflexes Acquisition and Increases Locomotor Activity During Mouse Postnatal Development.Frontiers in behavioral neuroscience · 2022Article
- Prenatal stress leads to deficits in brain development, mood related behaviors and gut microbiota in offspring.Neurobiology of stress · 2021Article
- Early life adoption shows rearing environment supersedes transgenerational effects of paternal stress on aggressive temperament in the offspring.Translational psychiatry · 2021Article
- Maternal Programming of Social Dominance via Milk Cytokines.iScience · 2020Article
- Early-life high-fat diet-induced obesity programs hippocampal development and cognitive functions via regulation of gut commensal Akkermansia muciniphila.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- The immune system and psychiatric disease: a basic science perspective.Clinical and experimental immunology · 2019Review
- Impaired Cerebellar Development in Mice Overexpressing VGF.Neurochemical research · 2019Article
- Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Maternal Brain TNF-α Programs Innate Fear in the Offspring.Current biology : CB · 2017Article
- Age at reproductive debut: Developmental predictors and consequences for lactation, infant mass, and subsequent reproduction in rhesus macaques (Macaca mulatta).American journal of physical anthropology · 2017Article
- Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.Cancer cell · 2017Article
- Defining age- and lactocrine-sensitive elements of the neonatal porcine uterine microRNA-mRNA interactome.Biology of reproduction · 2017Article
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8 authors at 2 institutions in 1 country.
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Abstract
Tumor necrosis factor α (TNF) is a proinflammatory cytokine with established roles in host defense and immune system organogenesis. We studied TNF function and found a previously unidentified physiological function that extends its effect beyond the host into the developing offspring. A partial or complete maternal TNF deficit, specifically in hematopoietic cells, resulted in reduced milk levels of the chemokines IP-10, MCP-1, MCP-3, MCP-5 and MIP-1β, which in turn augmented offspring postnatal hippocampal proliferation, leading to improved adult spatial memory in mice. These effects were reproduced by the postpartum administration of a clinically used anti-TNF agent. Chemokines, fed to suckling pups of TNF-deficient mothers, restored both postnatal proliferation and spatial memory to normal levels. Our results identify a TNF-dependent 'lactrocrine' pathway that programs offspring hippocampal development and memory. The level of ambient TNF is known to be downregulated by physical activity, exercise and adaptive stress. We propose that the maternal TNF-milk chemokine pathway evolved to promote offspring adaptation to post-weaning environmental challenges and competition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.