Evidence map›Paper›PMID 24291615›Full record

ArticleNeuroImage2014

Integration of sparse multi-modality representation and anatomical constraint for isointense infant brain MR image segmentation.

Li Wang, Feng Shi, Yaozong Gao, Gang Li, John H Gilmore, Weili Lin, Dinggang Shen

Abstract read
In one paragraph

Article in NeuroImage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Article
  6. Article
  7. Role of deep learning in infant brain MRI analysis.Magnetic resonance imaging · 2019
    Review
  8. Article
  9. Review
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  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. A Label-fusion-aided Convolutional Neural Network for Isointense Infant Brain Tissue Segmentation.Proceedings. IEEE International Symposium on Biomedical Imaging · 2018
    Article
  17. Ultrasound image-based thyroid nodule automatic segmentation using convolutional neural networks.International journal of computer assisted radiology and surgery · 2017
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Li WangIDEA Lab, Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA.
Feng ShiIDEA Lab, Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA.
Yaozong GaoIDEA Lab, Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA; Department of Computer Science, University of North Carolina at Chapel Hill, NC, USA.
Gang LiIDEA Lab, Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA.
John H GilmoreDepartment of Psychiatry, University of North Carolina at Chapel Hill, NC, USA.
Weili LinMRI Lab, Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA.
Dinggang ShenIDEA Lab, Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA; Department of Brain and Cognitive Engineering, Korea University, Seoul, Korea. Electronic address: dgshen@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Early Brain Development in TwinsR01MH070890 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2004 to 2014
$5.3M
Longitudinal Mapping of Human Brain Development in the First Years of LifeR01EB008374 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2009 to 2024
$5.1M
Development of Robust Brain Measurement Tools Informed by Ultrahigh Field 7T MRIR01EB006733 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2008 to 2020
$4.5M
Quantifying Brain Abnormality by Multimodality Neuroimage Analysis,R01AG041721 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, MINGXIA · 2012 to 2019
$3.0M
Early Brain Development in TwinsU01MH070890 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2015 to 2019
$2.9M
Infant Brain Measurement and Super-Resolution Atlas ConstructionR01MH100217 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEN, DINGGANG · 2013 to 2016
$2.3M
Assessing Large-scale Brain Connectivities in Mild Cognitive ImpairmentR01AG042599 · NIA · UNIVERSITY OF GEORGIA · PI LIU, TIANMING · 2013 to 2017
$1.4M
Fast, Robust Analysis of Large Population DataR01EB009634 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEN, DINGGANG · 2011 to 2014
$1.3M
Neonatal Brain SegmentationRC1MH088520 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEN, DINGGANG · 2009 to 2010
$1000k
NIA NIH HHS AG041721NIA NIH HHS AG042599NIA NIH HHS R01 AG041721NIA NIH HHS R01 AG042599NIBIB NIH HHS EB006733NIBIB NIH HHS EB008374NIBIB NIH HHS EB009634NIBIB NIH HHS R01 EB006733NIBIB NIH HHS R01 EB008374NIBIB NIH HHS R01 EB009634NIMH NIH HHS MH100217NIMH NIH HHS R01 MH070890NIMH NIH HHS R01 MH100217NIMH NIH HHS RC1 MH088520NIMH NIH HHS U01 MH070890
6 · The paper itself

Abstract

Segmentation of infant brain MR images is challenging due to poor spatial resolution, severe partial volume effect, and the ongoing maturation and myelination processes. During the first year of life, the brain image contrast between white and gray matters undergoes dramatic changes. In particular, the image contrast inverses around 6-8months of age, where the white and gray matter tissues are isointense in T1 and T2 weighted images and hence exhibit the extremely low tissue contrast, posing significant challenges for automated segmentation. In this paper, we propose a general framework that adopts sparse representation to fuse the multi-modality image information and further incorporate the anatomical constraints for brain tissue segmentation. Specifically, we first derive an initial segmentation from a library of aligned images with ground-truth segmentations by using sparse representation in a patch-based fashion for the multi-modality T1, T2 and FA images. The segmentation result is further iteratively refined by integration of the anatomical constraint. The proposed method was evaluated on 22 infant brain MR images acquired at around 6months of age by using a leave-one-out cross-validation, as well as other 10 unseen testing subjects. Our method achieved a high accuracy for the Dice ratios that measure the volume overlap between automated and manual segmentations, i.e., 0.889±0.008 for white matter and 0.870±0.006 for gray matter.

Indexed as

Diffusion Tensor ImagingBrainData Interpretation, StatisticalFemaleHumansImage Processing, Computer-AssistedInfantMaleNerve Fibers, MyelinatedAnatomical constraintInfant brain imagesIsointense stageLow contrastSparse representationTissue segmentation

Identifiers

PMID24291615
PMCPMC3944142
OpenAlexW2127558098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.