ArticleNeuroImage2014
Striatal dysfunction during reversal learning in unmedicated schizophrenia patients.
Article in NeuroImage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
150 citing papers in PubMed, 6 syntheses or guidelines pooled it, 263 citations in OpenAlex.
- Neurofunctional representations of instrumental learning in psychosis: a meta-analysis of neuroimaging studies.Psychological medicine · 2025Pooled it
- Abnormal prediction error processing in schizophrenia and depression.Human brain mapping · 2021Pooled it
- Meta-analytic evidence for altered mesolimbic responses to reward in schizophrenia.Human brain mapping · 2018Pooled it
- Association between structural and functional brain alterations in drug-free patients with schizophrenia: a multimodal meta-analysis.Journal of psychiatry & neuroscience : JPN · 2018Pooled it
- Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium.Psychological medicine · 2018Pooled it
- Patients with schizophrenia show aberrant patterns of basal ganglia activation: Evidence from ALE meta-analysis.NeuroImage. Clinical · 2017Pooled it
- Pharmacological Enhancement of Dopamine Neurotransmission Does Not Affect Illusory Pattern Perception.eNeuro · 2024Trial
- Ghrelin decreases sensitivity to negative feedback and increases prediction-error related caudate activity in humans, a randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Activation of D1 receptors affects human reactivity and flexibility to valued cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Behavioral and Neural Signatures of Reduced Updating of Alternative Options in Alcohol-Dependent Patients during Flexible Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Trial
- Reward-induced endogenous pain inhibition scales with action-outcome certainty in humans.Pain · 2026Article
- Inferring the causes of noise from binary outcomes: A normative theory of learning under uncertainty.Psychological review · 2026Article
- The hippocampus as a generative model.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Early Life Stress Affects Human Decision Making by Increasing Expectations of Volatility.Developmental science · 2026Article
- 16p11.2 duplication and NMDA receptor antagonism have distinct impacts on reward learning and decision making.Psychopharmacology · 2026Article
- Refining mechanistic models of hallucinations for enhanced translatability.Translational psychiatry · 2025Review
- Distinct Computational Mechanisms of Uncertainty Processing Explain Opposing Exploratory Behaviors in Anxiety and Apathy.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Addressing Altered Anticipation as a Transdiagnostic Target Through Computational Psychiatry.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Review
- The joint estimation of uncertainty and its relationship with psychotic-like traits and psychometric schizotypy.Npj mental health research · 2025Article
- 16p11.2 duplication shows early male-biased impacts on reward learning, but NMDA receptor antagonism reduces optimal choice selection in both wildtypes and 16p11.2 duplication.bioRxiv : the preprint server for biology · 2025Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
Subjects with schizophrenia are impaired at reinforcement-driven reversal learning from as early as their first episode. The neurobiological basis of this deficit is unknown. We obtained behavioral and fMRI data in 24 unmedicated, primarily first episode, schizophrenia patients and 24 age-, IQ- and gender-matched healthy controls during a reversal learning task. We supplemented our fMRI analysis, focusing on learning from prediction errors, with detailed computational modeling to probe task solving strategy including an ability to deploy an internal goal directed model of the task. Patients displayed reduced functional activation in the ventral striatum (VS) elicited by prediction errors. However, modeling task performance revealed that a subgroup did not adjust their behavior according to an accurate internal model of the task structure, and these were also the more severely psychotic patients. In patients who could adapt their behavior, as well as in controls, task solving was best described by cognitive strategies according to a Hidden Markov Model. When we compared patients and controls who acted according to this strategy, patients still displayed a significant reduction in VS activation elicited by informative errors that precede salient changes of behavior (reversals). Thus, our study shows that VS dysfunction in schizophrenia patients during reward-related reversal learning remains a core deficit even when controlling for task solving strategies. This result highlights VS dysfunction is tightly linked to a reward-related reversal learning deficit in early, unmedicated schizophrenia patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.