ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2014
Proteomics-based identification of plasma proteins and their association with the host-pathogen interaction in chronic typhoid carriers.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
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- The Low-Abundance Plasma Proteome Reveals Differentially Abundant Proteins Associated with Breast Implant Capsular Contracture: A Pilot Study.Proteomes · 2024Article
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- Revisiting PersistentPathogens (Basel, Switzerland) · 2021Review
- Why Is Eradicating Typhoid Fever So Challenging: Implications for Vaccine and Therapeutic Design.Vaccines · 2018Review
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- Proteomics in India: the clinical aspect.Clinical proteomics · 2016Review
- The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum.Infection and immunity · 2015Article
- Proprotein convertase FURIN constrains Th2 differentiation and is critical for host resistance against Toxoplasma gondii.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Salmonella chronic carriage: epidemiology, diagnosis, and gallbladder persistence.Trends in microbiology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent diagnostic tests are inadequate to detect typhoid cases, as well as the chronic carrier state, the sole reservoir of Salmonella enterica serovar Typhi. The current study was conducted to find new molecular signatures of pathogen/disease to understand the mechanism behind the host-pathogen interaction in enteric fever.
methodsProteomics-based studies were done to determine the expression of differentially expressed proteins in the plasma of controls, acute typhoid cases, and chronic typhoid carriers. Further, transcriptome-based analysis using reverse-transcriptase PCR (RT-PCR) was done in controls, acute typhoid cases, and chronic typhoid carriers.
resultsResults showed the upregulation of proprotein convertase subtilisin, furin, haptoglobin, and albumin in the plasma of chronic typhoid carriers. The elevation in mRNA expression of four differentially expressed proteins confirms the changes at the transcriptional level. Further, the increase in albumin and haptoglobin in chronic typhoid carriers shows their role in free radical generation, inflammation, and monocyte cell signaling.
conclusionThrough proteomics techniques, this study identified four proteins in the chronic typhoid carrier host that may have a role in the disease pathogenesis of enteric fever.
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