Evidence map›Paper›PMID 24291456›Full record

Trial reportContemporary clinical trials2014

Exercise for methamphetamine dependence: rationale, design, and methodology.

Larissa J Mooney, Christopher Cooper, Edythe D London, Joy Chudzynski, Brett Dolezal, Daniel Dickerson, Mary-Lynn Brecht, Jose Peñate, Richard A Rawson

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Contemporary clinical trials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

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  4. Effect of Exercise Training on Striatal Dopamine D2/D3 Receptors in Methamphetamine Users during Behavioral Treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Larissa J MooneyIntegrated Substance Abuse Programs, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, 11075 Santa Monica Blvd., Los Angeles, CA 90025, United States. Electronic address: lmooney@mednet.ucla.edu.
Christopher CooperExercise Physiology Research Laboratory, Division of Pulmonary Medicine, David Geffen School of Medicine, 10833 Le Conte 37-131 CHS, University of California, Los Angeles, Los Angeles, CA 90095, United States. Electronic address: ccooper@mednet.ucla.edu.
Edythe D LondonSemel Institute, David Geffen School of Medicine, University of California, 760 Westwood Plaza, Room C8-831, Los Angeles, CA 90024, United States. Electronic address: ELondon@mednet.ucla.edu.
Joy ChudzynskiIntegrated Substance Abuse Programs, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, 11075 Santa Monica Blvd., Los Angeles, CA 90025, United States. Electronic address: joychud@ucla.edu.
Brett DolezalExercise Physiology Research Laboratory, Division of Pulmonary Medicine, David Geffen School of Medicine, 10833 Le Conte 37-131 CHS, University of California, Los Angeles, Los Angeles, CA 90095, United States. Electronic address: BDolezal@mednet.ucla.edu.
Daniel DickersonIntegrated Substance Abuse Programs, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, 11075 Santa Monica Blvd., Los Angeles, CA 90025, United States. Electronic address: Daniel.dickerson@ucla.edu.
Mary-Lynn BrechtIntegrated Substance Abuse Programs, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, 11075 Santa Monica Blvd., Los Angeles, CA 90025, United States. Electronic address: LBrecht@mednet.ucla.edu.
Jose PeñateIntegrated Substance Abuse Programs, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, 11075 Santa Monica Blvd., Los Angeles, CA 90025, United States. Electronic address: jpenate@ucla.edu.
Richard A RawsonIntegrated Substance Abuse Programs, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, 11075 Santa Monica Blvd., Los Angeles, CA 90025, United States. Electronic address: rrawson@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Aerobic Exercise to Improve Outcomes of Treatment for Methamphetamine DependenceR01DA027633 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAWSON, RICHARD A · 2009 to 2014
$2.7M
NIDA NIH HHS R01 DA027633
6 · The paper itself

Abstract

backgroundEffective pharmacotherapies to treat methamphetamine (MA) dependence have not been identified, and behavioral therapies are marginally effective. Based on behavioral studies demonstrating the potential efficacy of aerobic exercise for improving depressive symptoms, anxiety, cognitive deficits, and substance use outcomes, the study described here is examining exercise as a potential treatment for MA-dependent individuals.

methodsThis study is randomizing 150 participants with MA dependence at a residential treatment facility for addictive disorders to receive either a thrice-weekly structured aerobic and resistance exercise intervention or a health education condition. Recruitment commenced in March, 2010. Enrollment and follow-up phases are ongoing, and recruitment is exceeding targeted enrollment rates.

conclusionsSeeking evidence for a possibly effective adjunct to traditional behavioral approaches for treatment of MA dependence, this study is assessing the ability of an 8-week aerobic and resistance exercise protocol to reduce relapse to MA use during a 12-week follow-up period after discharge from residential-based treatment. The study also is evaluating improvements in health and functional outcomes during and after the protocol. This paper describes the design and methods of the study.

Indexed as

MethamphetamineAdolescentAdultAmphetamine-Related DisordersExercise TherapyFemaleHumansMaleMiddle AgedResidential FacilitiesResistance TrainingSubstance Abuse Treatment CentersYoung AdultMethamphetamineAerobicExerciseMethamphetamine dependenceOutcomesTreatment intervention

Identifiers

PMID24291456
PMCPMC4431553
OpenAlexW1997188520

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.