Evidence map›Paper›PMID 24291279›Full record

ReviewJournal of the American College of Cardiology2014

Frailty assessment in the cardiovascular care of older adults.

Jonathan Afilalo, Karen P Alexander, Michael J Mack, Mathew S Maurer, Philip Green, Larry A Allen, Jeffrey J Popma, Luigi Ferrucci, Daniel E Forman

6 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the American College of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 476 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
476citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02635477 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Get Going: Fellow-Led Trial of an Accelerometer-Based Intervention to Promote Physical Activity in Frail Older Adults Transitioning From a Cardiovascular Hospitalization to Home

TypeinterventionalSponsorAmerican College of CardiologyRan2016 to 2017Enrolled150ConditionsCoronary Artery Disease, Heart FailureArmsIntervention, Control
NCT02992587 unknown statusnot on this mapstarted 2016, after this paper: background citation

Frailty In Cardiac Surgery Copenhagen Study

Typeobservational_patient_registrySponsorRigshospitalet, DenmarkRan2016 to 2020Enrolled600ConditionsComprehensive Assessment of FrailtyArmsCAF, Comprehensive assessment of frailty
NCT03289728 naterminatednot on this mapstarted 2018, after this paper: background citation

Evaluation of a Strategy Guided by Imaging Versus Systematic Coronary Angiography in Elderly Patients With Ischemia: a Multicentric Randomized Non Inferiority Trial.

TypeinterventionalSponsorUniversity Hospital, GrenobleRan2018 to 2025Enrolled588ConditionsMyocardial InfarctionArmsStress single photon emission CT (SPECT) or Stress ultrasound with dobutamine (DSE), Cornorary angioplasty
NCT04191915 completednot on this mapstarted 2020, after this paper: background citation

Assessment of Frailty in Elderly Patients Undergoing Elective Cardiac Surgery

TypeobservationalSponsorDr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research HospitalRan2020 to 2020Enrolled164ConditionsFrailty
NCT04962841 unknown statusnot on this mapstarted 2020, after this paper: background citation

Cognitive and Physical Impairment in Frail Older Adults

TypeobservationalSponsorUniversity of Campania Luigi VanvitelliRan2020 to 2023Enrolled485ConditionsFrailtyArmsNutraceuticals
NCT07701538 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Association Between Frailty and Central Venous Catheterization Difficulty in Adult Cardiac Surgery Patients: A Prospective Ultrasound-Based Observational Study

TypeobservationalSponsorAnkara City Hospital BilkentRan2026 to 2027Enrolled280ConditionsFrailty, Cardiac Surgery, Central Venous CatheterArmsUltrasound-Guided Internal Jugular Vein Catheterization
3 · Its place in the literature

Who cites it

476 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  19. Demographic and clinical differences between individuals with and without DXA scans in Denmark.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  20. Article

416 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jonathan AfilaloDivisions of Cardiology and Clinical Epidemiology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada. Electronic address: jonathan.afilalo@mcgill.ca.
Karen P AlexanderDivision of Cardiology, Duke University Medical Center, Durham, North Carolina.
Michael J MackDivision of Cardiothoracic Surgery, Baylor Health Care System, The Heart Hospital Baylor Plano, Plano, Texas.
Mathew S MaurerDivision of Cardiology, Columbia University Medical Center, New York, New York.
Philip GreenDivision of Cardiology, Columbia University Medical Center, New York, New York.
Larry A AllenDivision of Cardiology, University of Colorado School of Medicine, Aurora, Colorado.
Jeffrey J PopmaDivision of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Luigi FerrucciNational Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Daniel E FormanDivision of Cardiovascular Medicine, Brigham and Women's Hospital, VA Boston Healthcare Center, Boston, Massachusetts.

Funding

Frailty related risk: Poor physiologic reserve during and after valve replacementK23HL121142 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREEN, PHILIP · 2014 to 2016
$359k
NHLBI NIH HHS K23 HL121142NIA NIH HHS L30 AG040558
6 · The paper itself

Abstract

Due to the aging and increasingly complex nature of our patients, frailty has become a high-priority theme in cardiovascular medicine. Despite the recognition of frailty as a pivotal element in the evaluation of older adults with cardiovascular disease (CVD), there has yet to be a road map to facilitate its adoption in routine clinical practice. Thus, we sought to synthesize the existing body of evidence and offer a perspective on how to integrate frailty into clinical practice. Frailty is a biological syndrome that reflects a state of decreased physiological reserve and vulnerability to stressors. Upward of 20 frailty assessment tools have been developed, with most tools revolving around the core phenotypic domains of frailty-slow walking speed, weakness, inactivity, exhaustion, and shrinking-as measured by physical performance tests and questionnaires. The prevalence of frailty ranges from 10% to 60%, depending on the CVD burden, as well as the tool and cutoff chosen to define frailty. Epidemiological studies have consistently demonstrated that frailty carries a relative risk of >2 for mortality and morbidity across a spectrum of stable CVD, acute coronary syndromes, heart failure, and surgical and transcatheter interventions. Frailty contributes valuable prognostic insights incremental to existing risk models and assists clinicians in defining optimal care pathways for their patients. Interventions designed to improve outcomes in frail elders with CVD such as multidisciplinary cardiac rehabilitation are being actively tested. Ultimately, frailty should not be viewed as a reason to withhold care but rather as a means of delivering it in a more patient-centered fashion.

Indexed as

Frail ElderlyGeriatric AssessmentAgedAged, 80 and overCardiovascular DiseasesHumansProspective StudiesRetrospective StudiesSurveys and Questionnairescardiovascular diseaseelderlyfrailty

Identifiers

PMID24291279
PMCPMC4571179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.