ArticleCurrent biology : CB2013
Spindle assembly checkpoint of oocytes depends on a kinetochore structure determined by cohesin in meiosis I.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 45 citations in OpenAlex.
- Organization of replicated chromosomes by DNA loops and sister chromatid cohesion.Nature reviews. Molecular cell biology · 2026Review
- Chromosome Architecture Defined by the Meiosis-Specific Cohesin in Mammalian Germ Cells.Advances in experimental medicine and biology · 2026Review
- Meiosis-specific distal cohesion site decoupled from the kinetochore.Nature communications · 2025Article
- Distinct characteristics of the DNA damage response in mammalian oocytes.Experimental & molecular medicine · 2024Review
- SPIDR is required for homologous recombination during mammalian meiosis.Nucleic acids research · 2023Article
- CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I.Nature communications · 2022Article
- Loss of sister kinetochore co-orientation and peri-centromeric cohesin protection after meiosis I depends on cleavage of centromeric REC8.Developmental cell · 2021Article
- Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging.Nature communications · 2021Article
- The Cohesin Complex Subunit ZmSMC3 Participates in Meiotic Centromere Pairing in Maize.The Plant cell · 2020Article
- Article
- Meiotic prophase-like pathway for cleavage-independent removal of cohesin for chromosome morphogenesis.Current genetics · 2019Review
- The cohesin complex in mammalian meiosis.Genes to cells : devoted to molecular & cellular mechanisms · 2019Review
- Dynamics and control of sister kinetochore behavior during the meiotic divisions in Drosophila spermatocytes.PLoS genetics · 2018Article
- Mechanisms of kinetochore-microtubule attachment errors in mammalian oocytes.Development, growth & differentiation · 2018Review
- Cohesin acetyltransferase Esco2 regulates SAC and kinetochore functions via maintaining H4K16 acetylation during mouse oocyte meiosis.Nucleic acids research · 2017Article
- Smc1β is required for activation of SAC during mouse oocyte meiosis.Cell cycle (Georgetown, Tex.) · 2017Article
- Review
- Separase Is Required for Homolog and Sister Disjunction during Drosophila melanogaster Male Meiosis, but Not for Biorientation of Sister Centromeres.PLoS genetics · 2016Article
- Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway.The Journal of biological chemistry · 2016Article
- Erroneous Silencing of the Mitotic Checkpoint by Aberrant Spindle Pole-Kinetochore Coordination.Biophysical journal · 2015Article
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6 authors at 4 institutions in 2 countries.
Funding
Abstract
Since the dissolution of sister chromatid cohesion by separase and cyclin B destruction is irreversible, it is essential to delay both until all chromosomes have bioriented on the mitotic spindle. Kinetochores that are not correctly attached to the spindle generate the mitotic checkpoint complex (MCC), which inhibits the anaphase-promoting complex/cyclosome (APC/C) and blocks anaphase onset. This process is known as the spindle assembly checkpoint (SAC). The SAC is especially important in meiosis I, where bivalents consisting of homologous chromosomes held together by chiasmata biorient. Since the first meiotic division is unaffected by rare achiasmatic chromosomes or misaligned bivalents, it is thought that several tensionless kinetochores are required to produce sufficient MCC for APC/C inhibition. Consistent with this, univalents lacking chiasmata elicit a SAC-mediated arrest in Mlh1(-/-) oocytes. In contrast, chromatids generated by TEV protease-induced cohesin cleavage in Rec8(TEV/TEV) oocytes merely delay APC/C activation. Since the arrest of Mlh1(-/-)Rec8(TEV/TEV) oocytes is alleviated by TEV protease, even when targeted to kinetochores, we conclude that their SAC depends on cohesin as well as dedicated kinetochore proteins. This has important implications for aging oocytes, where cohesin deterioration will induce sister kinetochore biorientation and compromise MCC production, leading to chromosome missegregation and aneuploid fetuses.
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