Trial reportComputers in biology and medicine2013
Mitigating the effect of non-stationarity in spectral analysis-an application to neonate heart rate analysis.
Trial report in Computers in biology and medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Preoperative Heart Rate Variability and Parasympathetic Modulation in Newborns with Transposition of the Great Arteries Undergoing Arterial Switch Operation.Children (Basel, Switzerland) · 2026Article
- Preoperative autonomic failure in neonates with critical congenital heart disease.Early human development · 2025Article
- Prediction of outcome of hypoxic-ischemic encephalopathy in newborns undergoing therapeutic hypothermia using heart rate variability.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Central Autonomic Network and Heart Rate Variability in Premature Neonates.Developmental neuroscience · 2024Article
- Autonomic markers of extubation readiness in premature infants.Pediatric research · 2023Article
- Electroencephalogram in low-risk term newborns predicts neurodevelopmental metrics at age two years.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
- Cerebral cortical autonomic connectivity in low-risk term newborns.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Heart rate variability is depressed in the early transitional period for newborns with complex congenital heart disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Article
- Identifying an optimal epoch length for spectral analysis of heart rate of critically-ill infants.Computers in biology and medicine · 2019Article
- The effect of unilateral stroke on autonomic function in the term newborn.Pediatric research · 2019Article
- Autonomic Dysfunction in Neonates with Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia Impairs Physiological Responses to Routine Care Events.The Journal of pediatrics · 2018Article
- Pattern of brain injury and depressed heart rate variability in newborns with hypoxic ischemic encephalopathy.Pediatric research · 2017Article
- Inflammatory cytokine response and reduced heart rate variability in newborns with hypoxic-ischemic encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2017Observational
- Cerebral modulation of the autonomic nervous system in term infants.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Effect of Temperature on Heart Rate Variability in Neonatal ICU Patients With Hypoxic-Ischemic Encephalopathy.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Observational
- Premature Infants Rehospitalized because of an Apparent Life-Threatening Event Had Distinctive Autonomic Developmental Trajectories.American journal of respiratory and critical care medicine · 2016Article
- Heart rate variability in encephalopathic newborns during and after therapeutic hypothermia.Journal of perinatology : official journal of the California Perinatal Association · 2014Article
- Detrended fluctuation analysis of non-stationary cardiac beat-to-beat interval of sick infants.Europhysics letters · 2014Article
- Cerebral pressure passivity in newborns with encephalopathy undergoing therapeutic hypothermia.Frontiers in human neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In order to mitigate the effect of non-stationarity in frequency domain analysis of data, we propose a modification to the power spectral estimation, a widely used technique to characterize physiological signals. Spectral analysis requires partitioning data into smaller epochs determined by the desired frequency resolution. The modified approach proposed here involves dividing the data within each epoch by the standard deviation of the data for that epoch. We applied this modified approach to cardiac beat-to-beat interval data recorded from a newborn infant undergoing hypothermia treatment for birth asphyxia. The critically ill infant had episodes of tachyarrhythmia, distributed sporadically throughout the study, which affected the stationarity of the heart rate. Over the period of continuous heart rate recording, the infant's clinical course deteriorated progressively culminating in death. Coinciding with this clinical deterioration, the heart rate signal showed striking changes in both low-frequency and high-frequency power indicating significant impairment of the autonomic nervous system. The standard spectral approach failed to capture these phenomena because of the non-stationarity of the signal. Conversely, the modified approach proposed here captured the deteriorating physiology of the infant clearly.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.