ArticleCell reports2013
Germ plasm anchoring is a dynamic state that requires persistent trafficking.
Article in Cell reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Article
- Proteins rather than mRNAs regulate nucleation and persistence of Oskar germ granules in Drosophila.Cell reports · 2023Article
- Plasticity of Drosophila germ granules during germ cell development.PLoS biology · 2023Article
- Go with the flow - bulk transport by molecular motors.Journal of cell science · 2023Review
- Sinhcaf-dependent histone deacetylation is essential for primordial germ cell specification.EMBO reports · 2022Article
- Computational modeling offers new insight into Drosophila germ granule development.Biophysical journal · 2022Article
- mLoc-mRNA: predicting multiple sub-cellular localization of mRNAs using random forest algorithm coupled with feature selection via elastic net.BMC bioinformatics · 2021Article
- Patterning the Drosophila embryo: A paradigm for RNA-based developmental genetic regulation.Wiley interdisciplinary reviews. RNA · 2020Review
- Sequence-Independent Self-Assembly of Germ Granule mRNAs into Homotypic Clusters.Molecular cell · 2020Article
- Drosophila pericentrin-like protein promotes the formation of primordial germ cells.Genesis (New York, N.Y. : 2000) · 2020Article
- Article
- Germ granules in Drosophila.Traffic (Copenhagen, Denmark) · 2019Review
- Ooplasmic flow cooperates with transport and anchorage inThe Journal of cell biology · 2018Article
- Article
- Stochastic Seeding Coupled with mRNA Self-Recruitment Generates Heterogeneous Drosophila Germ Granules.Current biology : CB · 2018Article
- mRNA quantification using single-molecule FISH in Drosophila embryos.Nature protocols · 2017Article
- Long Oskar Controls Mitochondrial Inheritance in Drosophila melanogaster.Developmental cell · 2016Article
- Article
- Fixed and live visualization of RNAs in Drosophila oocytes and embryos.Methods (San Diego, Calif.) · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Localized cytoplasmic determinants packaged as ribonucleoprotein (RNP) particles direct embryonic patterning and cell fate specification in a wide range of organisms. Once established, the asymmetric distributions of such RNP particles must be maintained, often over considerable developmental time. A striking example is the Drosophila germ plasm, which contains RNP particles whose localization to the posterior of the egg during oogenesis results in their asymmetric inheritance and segregation of germline from somatic fates in the embryo. Although actin-based anchoring mechanisms have been implicated, high-resolution live imaging revealed persistent trafficking of germ plasm RNP particles at the posterior cortex of the Drosophila oocyte. This motility relies on cortical microtubules, is mediated by kinesin and dynein motors, and requires coordination between the microtubule and actin cytoskeletons. Finally, we show that RNP particle motility is required for long-term germ plasm retention. We propose that anchoring is a dynamic state that renders asymmetries robust to developmental time and environmental perturbations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.