ArticleBiological psychiatry2014
WWC1 genotype modulates age-related decline in episodic memory function across the adult life span.
Article in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pooled it
- Long-read whole-genome sequencing of SHR rat substrains with distinct substance use phenotypes.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- PICK1 links KIBRA and AMPA receptor subunit GluA2 in coiled-coil-driven supramolecular complexes.The Journal of biological chemistry · 2025Article
- KIBRA single nucleotide polymorphism is associated with hippocampal subfield volumes and cognition across development.Brain structure & function · 2024Article
- KIBRA regulates activity-induced AMPA receptor expression and synaptic plasticity in an age-dependent manner.iScience · 2022Article
- Brain microstructural alterations in the left precuneus mediate the association between KIBRA polymorphism and working memory in healthy adults: a diffusion kurtosis imaging study.Brain imaging and behavior · 2022Article
- The relationship between cognitive decline and a genetic predictor of educational attainment.Social science & medicine (1982) · 2019Article
- KIBRA T allele influences memory performance and progression of cognitive decline: a 7-year follow-up study in subjective cognitive decline and mild cognitive impairment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden.Scientific reports · 2018Article
- Aging and a genetic KIBRA polymorphism interactively affect feedback- and observation-based probabilistic classification learning.Neurobiology of aging · 2018Article
- Article
- Age-Modulated Associations betweenFrontiers in aging neuroscience · 2017Article
- Impact of KIBRA Polymorphism on Memory Function and the Hippocampus in Older Adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Serum KIBRA mRNA and Protein Expression and Cognitive Functions in Depression.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Genetics and functional imaging: effects of APOE, BDNF, COMT, and KIBRA in aging.Neuropsychology review · 2015Review
- APOE ε4 genotype predicts memory for everyday activities.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2015Article
- Forced arm use is superior to voluntary training for motor recovery and brain plasticity after cortical ischemia in rats.Experimental & translational stroke medicine · 2014Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundEpisodic memory (EM) declines with age and the rate of decline is variable across individuals. A single nucleotide polymorphism (rs17070145) in the WWC1 gene that encodes the KIBRA protein critical for long-term potentiation and memory consolidation has previously been associated with EM performance, as well as differences in hippocampal engagement during EM tasks using functional magnetic resonance imaging (fMRI). In the current study, we explore the effect of this polymorphism on EM-related activity and cognitive performance across the adult life span using fMRI.
methodsTwo hundred thirty-two healthy, Caucasian subjects (18-89 years) completed a battery of cognitive tests, as well as an EM task during an fMRI scan.
resultsWWC1 T carriers had significantly better delayed recall performance than CC individuals (p = .006). The relationship between increasing age and recall scores (immediate and delayed) was also significantly different between WWC1 genotype groups (p = .01). In addition to the age-related decline in hippocampal formation (HF) activation (p < .05; false discovery ratesmall volume correction-HF-region of interest), we observed an age by WWC1 genotype interaction on HF activation during encoding and retrieval. The CC group showed a significant negative association between HF activity and increasing age, while no such association was observed in the T carrier group (left HF p = .04; r-z correlation difference during encoding and retrieval; right HF p = .0008; r-z correlation difference during retrieval).
conclusionsOur results show a dynamic relationship between rs17070145 polymorphism and increasing age on neuronal activity in the hippocampal region.
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