ArticleJACC. Cardiovascular imaging2014
Magnesium intake is inversely associated with coronary artery calcification: the Framingham Heart Study.
Article in JACC. Cardiovascular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: a meta-analysis of randomized controlled trials.The American journal of clinical nutrition · 2017Pooled it
- Association between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses.The American journal of clinical nutrition · 2015Pooled it
- Trial
- Diet patterns are associated with progression of coronary artery calcification and differ across race/ethnicity: The Multi-Ethnic Study of Atherosclerosis.American journal of preventive cardiology · 2026Article
- Impact of nine dietary minerals on the risk of chronic kidney disease: a multi-model analysis in US adults using NHANES data.Journal of clinical biochemistry and nutrition · 2026Article
- Domestic water hardness, genetic susceptibility, and risk of symptomatic abdominal aortic aneurysm: a cohort study of UK biobank.BMC cardiovascular disorders · 2026Article
- Dietary Calcium to Magnesium Ratio and Risk of Cardiovascular Diseases.Biological trace element research · 2025Article
- Low-fibre diet is associated with high-risk coronary plaque features.Cardiovascular research · 2025Article
- The effect of dietary micronutrient intake on abdominal aortic calcification: a study protocol for systematic review and meta-analysis.BMJ open · 2025Article
- Association of magnesium intake with predicted atherosclerotic lesions and cardiovascular risk in young adults based on PDAY score: a cross-sectional study.BMC public health · 2024Article
- High Blood Pressure and Impaired Brain Health: Investigating the Neuroprotective Potential of Magnesium.International journal of molecular sciences · 2024Review
- Association of Intake of Whole Grains with Health Outcomes in the Chronic Renal Insufficiency Cohort Study.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
- Cardiovascular and All-Cause Mortality Is Affected by Serum Magnesium and Diet Pattern in a Cohort of Dialysis Patients.Journal of clinical medicine · 2024Article
- Magnesium and Vascular Calcification in Chronic Kidney Disease: Current Insights.International journal of molecular sciences · 2024Review
- Age differences in the association of body mass index-defined obesity with abdominal aortic calcification.Frontiers in endocrinology · 2024Article
- Magnesium Administration in Chronic Kidney Disease.Nutrients · 2023Review
- Magnesium and Zinc Intake Ratio Mediates the Increase of Coronary Artery Calcification through Upregulating Interleukin 6.The Libyan journal of medicine · 2022Article
- Dietary fiber and prevalence of abdominal aortic calcification in the United States (from the national health and nutrition examination survey data [2013-2014]).Nutrition journal · 2022Article
- Magnesium intake and vascular structure and function: the Hoorn Study.European journal of nutrition · 2022Article
- Magnesium to prevent kidney disease-associated vascular calcification: crystal clear?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe aim of this study was to examine whether magnesium intake is associated with coronary artery calcification (CAC) and abdominal aortic calcification (AAC).
backgroundAnimal and cell studies suggest that magnesium may prevent calcification within atherosclerotic plaques underlying cardiovascular disease. Little is known about the association of magnesium intake and atherosclerotic calcification in humans.
methodsWe examined cross-sectional associations of self-reported total (dietary and supplemental) magnesium intake estimated by food frequency questionnaire with CAC and AAC in participants of the Framingham Heart Study who were free of cardiovascular disease and underwent Multi-Detector Computed Tomography (MDCT) of the heart and abdomen (n = 2,695; age: 53 ± 11 years), using multivariate-adjusted Tobit regression. CAC and AAC were quantified using modified Agatston scores (AS). Models were adjusted for age, sex, body mass index, smoking status, systolic blood pressure, fasting insulin, total-to-high-density lipoprotein cholesterol ratio, use of hormone replacement therapy (women only), menopausal status (women only), treatment for hyperlipidemia, hypertension, cardiovascular disease prevention, or diabetes, as well as self-reported intake of calcium, vitamins D and K, saturated fat, fiber, alcohol, and energy. Secondary analyses included logistic regressions of CAC and AAC outcomes as cut-points (AS >0 and AS ≥90th percentile for age and sex), as well as sex-stratified analyses.
resultsIn fully adjusted models, a 50-mg/day increment in self-reported total magnesium intake was associated with 22% lower CAC (p < 0.001) and 12% lower AAC (p = 0.07). Consistent with these observations, the odds of having any CAC were 58% lower (p trend: <0.001) and any AAC were 34% lower (p trend: 0.01), in those with the highest compared to those with the lowest magnesium intake. Stronger inverse associations were observed in women than in men.
conclusionsIn community-dwelling participants free of cardiovascular disease, self-reported magnesium intake was inversely associated with arterial calcification, which may play a contributing role in magnesium's protective associations in stroke and fatal coronary heart disease.
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Registered trials
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