Evidence map›Paper›PMID 24290442›Full record

ReviewThe journal of pain2013

The association of sleep and pain: an update and a path forward.

Patrick H Finan, Burel R Goodin, Michael T Smith

6 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of pain, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 754 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
754citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03335527 phase4completednot on this mapstarted 2017, after this paper: background citation

Impact of Low-Dose Dexmedetomidine on Sleep Quality in Mechanical Ventilation Patients After Surgery in Intensive Care Unit: a Pilot Randomized, Double-Blind, Placebo-Controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2017 to 2019Enrolled80ConditionsAged, Postoperative Period, Intensive Care Units, Mechanical Ventilation ComplicationArmsDexmedetomidine, Placebo (normal saline)
NCT05718024 phase4completednot on this mapstarted 2023, after this paper: background citation

Impact of Night-time Dexmedetomidine-esketamine Infusion on Sleep Quality of Patients With Mechanical Ventilation or High-flow Nasal Cannula Oxygen Therapy in ICU: a Randomized Controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2023 to 2025Enrolled174ConditionsIntensive Care Unit, Mechanical Ventilation, Dexmedetomidine, EsketamineArmsDexmedetomidine-esketamine, Routine sedation and analgesia
NCT06468436 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Dexmedetomidine-Esketamine Combination for Sedation and Analgesia on Delirium in ICU Patients With Mechanical Ventilation: A Multicenter Randomized Trial

TypeinterventionalSponsorPeking University First HospitalRan2025 to 2030Enrolled1,508ConditionsAged, Intensive Care Units, Ventilators, Mechanical, DexmedetomidineArmsDexmedetomidine-Esketamine Combination, Dexmedetomidine
NCT06566482 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia for Postoperative Sleep Promotion in Patients at High-risk of Obstructive Sleep Apnea: A Randomized Trial

TypeinterventionalSponsorPeking University First HospitalRan2024 to 2025Enrolled100ConditionsObstructive Sleep Apnea, Surgery, Dexmedetomidine, EsketamineArmsDexmedetomidine-esketamine combination, Placebo
NCT07376811 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect Of Sleeping Posture Guidance On Sleep Quality In Patients With Rotator Cuff Syndrome Undergoing Physical Therapy: A Randomized Clinical Trial

TypeinterventionalSponsorFederal University of São PauloRan2026 to 2029Enrolled64ConditionsRotator Cuff Syndrome, Rotator Cuff Injury, Sleep Disorder (Disorder)ArmsPhysical Therapy, Physical Therapy + Sleep Guidance
NCT07547774 recruitingnot on this mapstarted 2026, after this paper: background citation

Role of Preoperative Sleep Quality in Predicting Postoperative Inflammation, Pain Severity, and Analgesic Requirement After Breast Cancer Surgery

TypeobservationalSponsorDr Abdurrahman Yurtaslan Ankara Oncology Training and Research HospitalRan2026 to 2026Enrolled150ConditionsBreast Cancer, Postoperative Pain, InflammationArmsPreoperative Sleep Quality Assessment (PSQI)
3 · Its place in the literature

Who cites it

754 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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694 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Patrick H FinanDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: pfinan1@jhu.edu.
Burel R Goodin
Michael T Smith

Funding

Interdisciplinary Training in Biobehavioral Pain ResearchT32NS070201 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DONG, XINZHONG, SMITH, MICHAEL T · 2010 to 2024
$3.6M
Sleep Disturbance, Central Pain Modulation, and Clinical Pain in OsteoarthritisR01AR054871 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI SMITH, MICHAEL T · 2007 to 2011
$3.1M
Effects of Insomnia on Pain & Function in Osteoarthritis:The Role of InflammationR01AR059410 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI SMITH, MICHAEL T · 2010 to 2013
$1.3M
NIAMS NIH HHS R01 AR05487NIAMS NIH HHS R01 AR054871NIAMS NIH HHS R01 AR059410NIAMS NIH HHS R01AR059410NIA NIH HHS L30 AG040467NINDS NIH HHS T32 NS070201
6 · The paper itself

Abstract

unlabelledAmple evidence suggests that sleep and pain are related. However, many questions remain about the direction of causality in their association, as well as mechanisms that may account for their association. The prevailing view has generally been that they are reciprocally related. The present review critically examines the recent prospective and experimental literature (2005-present) in an attempt to update the field on emergent themes pertaining to the directionality and mechanisms of the association of sleep and pain. A key trend emerging from population-based longitudinal studies is that sleep impairments reliably predict new incidents and exacerbations of chronic pain. Microlongitudinal studies employing deep subjective and objective assessments of pain and sleep support the notion that sleep impairments are a stronger, more reliable predictor of pain than pain is of sleep impairments. Recent experimental studies suggest that sleep disturbance may impair key processes that contribute to the development and maintenance of chronic pain, including endogenous pain inhibition and joint pain. Several biopsychosocial targets for future mechanistic research on sleep and pain are discussed, including dopamine and opioid systems, positive and negative affect, and sociodemographic factors. PERSPECTIVE: This critical review examines the recent prospective and experimental research (2005-present) on the association of sleep and pain in an attempt to identify trends suggestive of directionality and potential mechanisms. An update on this literature is needed to guide future clinical efforts to develop and augment treatments for chronic sleep disturbance and chronic pain.

Indexed as

HumansLongitudinal StudiesPainPain ManagementProspective StudiesSleepSleep Wake DisordersChronic paininsomnialongitudinalsleepsleep deprivation

Identifiers

PMID24290442
PMCPMC4046588

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.