Trial reportThe Journal of allergy and clinical immunology2014
Obesity and adiposity indicators, asthma, and atopy in Puerto Rican children.
Trial report in The Journal of allergy and clinical immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Differential gene expression in nasal airway epithelium from overweight or obese youth with asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Pooled it
- Effect of childhood BMI on asthma: a systematic review and meta-analysis of case-control studies.BMC pediatrics · 2018Pooled it
- Maternal obesity in pregnancy, gestational weight gain, and risk of childhood asthma.Pediatrics · 2014Pooled it
- A Multiomics Approach to Identify Genes Associated with Childhood Asthma Risk and Morbidity.American journal of respiratory cell and molecular biology · 2017Trial
- Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese.The journal of allergy and clinical immunology. In practiceTrial
- Adiposity measures and childhood asthma: one size does not fit all.Pediatric research · 2026Article
- Article
- Associations between body weight, asthma burden, and type 2 inflammation among under-resourced children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Obesity: Next game changer of allergic airway diseases?Clinical and translational medicine · 2025Review
- Association of relative fat mass with asthma: inflammatory markers as potential mediators.Lipids in health and disease · 2025Article
- Are single-nucleotide polymorphisms previously linked to inhaled corticosteroid response associated with obese-asthma in children?Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Article
- Associations of urinary organophosphate esters metabolites with asthma and lung function in adolescents.Journal of exposure science & environmental epidemiology · 2024Article
- Association between Weight for Length and the Severity of Respiratory Morbidity in Preterm Infants.Children (Basel, Switzerland) · 2024Article
- Association between body mass index and atopic dermatitis among adolescents: Findings from a national cross-sectional study in Korea.PloS one · 2024Article
- Sex, Ethnicity, Body Mass Index, and Environmental Exposures Associated With NSAID-Exacerbated Respiratory Disease Symptom Sequence.The journal of allergy and clinical immunology. In practice · 2023Article
- Being overweight and born in the spring are associated with an increased risk for rhinitis.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Correlation Between Allergic Rhinitis and Body Mass Index: An Observational Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Asthma interactions between obesity and other risk factors.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Review
- Association between Serum Total and Specific Immunoglobulin E Levels and Body Height: A Cross-Sectional Study of Children and Adolescents.Children (Basel, Switzerland) · 2022Article
- Persistent overweight or obesity, lung function, and asthma exacerbations in Puerto Rican youth.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundWhether adiposity indicators other than body mass index (BMI) should be used in studies of childhood asthma is largely unknown. The role of atopy in "obese asthma" is also unclear.
objectivesTo examine the relationship among adiposity indicators, asthma, and atopy in Puerto Rican children, and to assess whether atopy mediates the obesity-asthma association.
methodsIn a study of Puerto Rican children with (n = 351) and without (n = 327) asthma, we measured BMI, percent of body fat, waist circumference, and waist-to-hip ratio. The outcomes studied included asthma, lung function, measures of atopy, and, among cases, indicators of asthma severity or control. We performed mediation analysis to assess the contribution of atopy to the relationship between adiposity and asthma.
resultsBMI, percent of body fat, and waist circumference were associated with increased odds of asthma. Among cases, all 3 measures were generally associated with lung function, asthma severity/control, and atopy; however, there were differences depending on the adiposity indicator analyzed. Atopy considerably mediated the adiposity-asthma association in this population: allergic rhinitis accounted for 22% to 53% of the association with asthma, and sensitization to cockroach mediated 13% to 20% of the association with forced vital capacity and 29% to 42% of the association with emergency department visits for asthma.
conclusionsAdiposity indicators are associated with asthma, asthma severity/control, and atopy in Puerto Rican children. Atopy significantly mediates the effect of adiposity on asthma outcomes. Longitudinal studies are needed to further investigate the causal role, if any, of adiposity distribution and atopy on "obese asthma" in childhood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.