Trial reportMayo Clinic proceedings2013
Maternal vitamin D supplementation to improve the vitamin D status of breast-fed infants: a randomized controlled trial.
Trial report in Mayo Clinic proceedings, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01240265 (Maternal Oral Vitamin D Supplementation Via Daily or Monthly Regimens and the Effect on Levels of Vitamin D in Human Milk and Infant Serum), which is not on this map. Cited by 45 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Maternal Oral Vitamin D Supplementation Via Daily or Monthly Regimens and the Effect on Levels of Vitamin D in Human Milk and Infant Serum
Who cites it
45 citing papers in PubMed, 7 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Vitamin D supplementation in pregnant or breastfeeding women or young children for preventing asthma.The Cochrane database of systematic reviews · 2025Pooled it
- Evaluating the relationship between the nutrient intake of lactating women and their breast milk nutritional profile: a systematic review and narrative synthesis.The British journal of nutrition · 2024Pooled it
- Calcium, zinc, and vitamin D in breast milk: a systematic review and meta-analysis.International breastfeeding journal · 2023Pooled it
- Nutritional supplements and mother's milk composition: a systematic review of interventional studies.International breastfeeding journal · 2021Pooled it
- Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health.The Cochrane database of systematic reviews · 2020Pooled it
- Vitamin D in Breastfed Infants: Systematic Review of Alternatives to Daily Supplementation.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Supplementation with multiple micronutrients for breastfeeding women for improving outcomes for the mother and baby.The Cochrane database of systematic reviews · 2016Pooled it
- Vitamins A, D, E, and K Intakes, Status, and Breastmilk Concentrations in Breastfeeding Women in Ireland.The Journal of nutrition · 2026Trial
- Comparison of Infant Bone Mineral Content and Density After Infant Daily Oral Vit D 400 IU Supplementation Versus Nursing Mother Oral 6,400 IU Supplementation: A Randomized Controlled Lactation Study.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2022Trial
- Multiple Micronutrients, Lutein, and Docosahexaenoic Acid Supplementation during Lactation: A Randomized Controlled Trial.Nutrients · 2020Trial
- Trial
- Maternal Versus Infant Vitamin D Supplementation During Lactation: A Randomized Controlled Trial.Pediatrics · 2015Trial
- Trial
- Breastfeeding: The Multifaceted Impact on Child Development and Maternal Well-Being.Nutrients · 2025Review
- Sulfated vitamin D metabolites represent prominent roles in serum and in breastmilk of lactating women.Clinical nutrition (Edinburgh, Scotland) · 2024Article
- Longitudinal Changes in Human Milk Minerals and Vitamins in the Chinese Population: A Scoping Review.Nutrients · 2024Article
- Article
- Nutritional Status of Breastfeeding Mothers and Impact of Diet and Dietary Supplementation: A Narrative Review.Nutrients · 2024Review
- Analysis of vitamin DJournal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2024Article
- Immunologic, Anti-Inflammatory, and Anti-Muscle Damage Profile of Supplemented Vitamin DBiology · 2023Article
Corrections and comments
- Commented on by
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo determine whether a single monthly supplement is as effective as a daily maternal supplement in increasing breast milk vitamin D to achieve vitamin D sufficiency in their infants. PATIENTS AND
methodsForty mothers with exclusively breast-fed infants were randomized to receive oral cholecalciferol (vitamin D3) 5000 IU/d for 28 days or 150,000 IU once. Maternal serum, breast milk, and urine were collected on days 0, 1, 3, 7, 14, and 28; infant serum was obtained on days 0 and 28. Enrollment occurred between January 7, 2011, and July 29, 2011.
resultsIn mothers given daily cholecalciferol, concentrations of serum and breast milk cholecalciferol attained steady levels of 18 and 8 ng/mL, respectively, from day 3 through 28. In mothers given the single dose, serum and breast milk cholecalciferol peaked at 160 and 40 ng/mL, respectively, at day 1 before rapidly declining. Maternal milk and serum cholecalciferol concentrations were related (r=0.87). Infant mean serum 25-hydroxyvitamin D concentration increased from 17±13 to 39±6 ng/mL in the single-dose group and from 16±12 to 39±12 ng/mL in the daily-dose group (P=.88). All infants achieved serum 25-hydroxyvitamin D concentrations of more than 20 ng/mL.
conclusionEither single-dose or daily-dose cholecalciferol supplementation of mothers provided breast milk concentrations that result in vitamin D sufficiency in breast-fed infants. CLINICAL
trial registrationclinicaltrials.gov NCT01240265.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.