Trial reportMolecular oral microbiology2014
The effect of arginine on oral biofilm communities.
Trial report in Molecular oral microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 134 citations in OpenAlex.
- Arginine modulates the pH, microbial composition, and matrix architecture of biofilms from caries-active patients.International journal of oral science · 2025Trial
- Metabolic Profile of Supragingival Plaque Exposed to Arginine and Fluoride.Journal of dental research · 2019Trial
- [Age-Related Changes in the Oral Microbiota].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- The Cariostatic Mechanisms of Fluoride-An Updated Review.Dentistry journal · 2026Review
- Streptococcus dentisani and Streptococcus mutans in dental biofilm of preschoolers with and without early childhood caries: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Putative Prebiotics Can Disrupt 3D Architecture and Modulate the Microbial Population to Prevent Cariogenic Biofilm Build-Up In Vitro.ACS omega · 2026Article
- Oral Dysbiosis and Neuroinflammation: Implications for Alzheimer's, Parkinson's and Mood Disorders.Microorganisms · 2026Review
- Developmental ecology of the infant oral ecosystem: a framework for early childhood caries.Frontiers in oral health · 2026Review
- The subgingival microbiome in periodontitis: from ecological dysbiosis and metabolic reprogramming to precision interventions.Frontiers in microbiology · 2026Review
- A novel dual-targeting strategy to suppress cariogenic bacteria and biofilms with engineered ARG/FBG bioactive composites.Regenerative biomaterials · 2026Article
- Natural Compounds in Oral Microbiota Modulation and Caries Prevention: A Systematic Review.Dentistry journal · 2025Review
- Unveiling Oral Health Impacts of Vaping in African Americans through Untargeted Metabolomics and Proteomics.Environment & health (Washington, D.C.) · 2025Article
- Decoding the role of the arginine dihydrolase pathway in shaping human gut community assembly and health-relevant metabolites.Cell systems · 2025Article
- A Pyrroloquinazoline Analogue Regulated Streptococcus mutans and Streptococcus sanguinis Dual-Species Biofilms.International dental journal · 2025Article
- Arginine combination with fluoride and calcium glycerophosphate: effects of concentration and on biofilm fluid.Future microbiology · 2025Article
- Arginine inhibits cross-kingdom interactions and synergistic cariogenicity betweenFrontiers in cellular and infection microbiology · 2025Article
- Evaluation of the Antibacterial and Anti-Biofilm Activity of Chitosan-Arginine Nanoparticles and Sodium Fluoride againstInternational journal of molecular and cellular medicine · 2025Article
- Modulation of the Human Microbiome: Probiotics, Prebiotics, and Microbial Transplants.Advances in experimental medicine and biology · 2025Review
- Arginine impacts aggregation, biofilm formation, and antibiotic susceptibility inbioRxiv : the preprint server for biology · 2024Article
- Heterogeneous lineage-specific arginine deiminase expression within dental microbiome species.Microbiology spectrum · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Alkali production by oral bacteria via the arginine deiminase system (ADS) increases the pH of oral biofilms and reduces the risk for development of carious lesions. This study tested the hypothesis that increased availability of arginine in the oral environment through an exogenous source enhances the ADS activity levels in saliva and dental plaque. Saliva and supra-gingival plaque samples were collected from 19 caries-free (CF) individuals (DMFT = 0) and 19 caries-active (CA) individuals (DMFT ≥ 2) before and after treatment, which comprised the use of a fluoride-free toothpaste containing 1.5% arginine, or a regular fluoride-containing toothpaste twice daily for 4 weeks. ADS activity was measured by quantification of ammonia produced from arginine by oral samples at baseline, after washout period, 4 weeks of treatment, and 2 weeks post-treatment. Higher ADS activity levels were observed in plaque samples from CF compared to those of CA individuals (P = 0.048) at baseline. The use of the arginine toothpaste significantly increased ADS activity in plaque of CA individuals (P = 0.026). The plaque microbial profiles of CA treated with the arginine toothpaste showed a shift in bacterial composition to a healthier community, more similar to that of CF individuals. Thus, an anti-caries effect may be expected from arginine-containing formulations due in large part to the enhancement of ADS activity levels and potential favorable modification to the composition of the oral microbiome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.