ArticleGenes, brain, and behavior2014
Propensity for social interaction predicts nicotine-reinforced behaviors in outbred rats.
Article in Genes, brain, and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Sex differences in nicotine intravenous self-administration: A meta-analytic review.Physiology & behavior · 2019Pooled it
- Article
- The role of β-Nicotyrine in E-Cigarette abuse liability I: Drug Discrimination.bioRxiv : the preprint server for biology · 2024Article
- Inbred rat heredity and sex affect oral oxycodone self-administration and augmented intake in long sessions: correlations with anxiety and novelty-seeking.bioRxiv : the preprint server for biology · 2024Article
- Sex Differences in Social Cognition.Current topics in behavioral neurosciences · 2023Review
- Genome-Wide Association Study on Three Behaviors Tested in an Open Field in Heterogeneous Stock Rats Identifies Multiple Loci Implicated in Psychiatric Disorders.Frontiers in psychiatry · 2022Article
- Strain and sex matters: Differences in nicotine self-administration between outbred and recombinase-driver transgenic rat lines.Experimental and clinical psychopharmacology · 2021Article
- Housing conditions during self-administration determine motivation for cocaine in mice following chronic social defeat stress.Psychopharmacology · 2021Article
- Article
- Administration ofFrontiers in behavioral neuroscience · 2020Article
- Using Heterogeneous Stocks for Fine-Mapping Genetically Complex Traits.Methods in molecular biology (Clifton, N.J.) · 2019Review
- Social and anxiety-like behaviors contribute to nicotine self-administration in adolescent outbred rats.Scientific reports · 2018Article
- MicroRNA cluster miR199a/214 are differentially expressed in female and male rats following nicotine self-administration.Scientific reports · 2018Article
- Sex differences in the brain: Implications for behavioral and biomedical research.Neuroscience and biobehavioral reviews · 2018Review
- Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats.Scientific reports · 2017Article
- Individual Variations in the Mechanisms of Nicotine Seeking: A Key for Research on Nicotine Dependence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Heterogeneous Stock Populations for Analysis of Complex Traits.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Alterations in alpha5* nicotinic acetylcholine receptors result in midbrain- and hippocampus-dependent behavioural and neural impairments.Psychopharmacology · 2016Article
- Sex differences in neurotensin and substance P following nicotine self-administration in rats.Synapse (New York, N.Y.) · 2016Article
- Socially acquired nicotine self-administration with an aversive flavor cue in adolescent female rats.Psychopharmacology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Social and genetic factors can influence smoking behavior. Using olfactogustatory stimuli as the sensory cue for intravenous nicotine self-administration (SA), we previously showed that social learning of nicotine contingent odor cue prevented rats from developing conditioned taste aversion and allowed them to instead establish stable nicotine SA. We hypothesized that genetic factors influenced socially acquired nicotine SA. A heterogeneous stock (HS; N/NIH) of outbred rats was trained to self-administer nicotine using the social learning protocol. Both male and female HS rats acquired nicotine SA, but females self-administered more nicotine than males. After extinction, the context previously paired with nicotine SA, in conjunction with socially transmitted drug cues, was sufficient to cause reinstatement of drug-seeking behavior. Wide variation in both nicotine intake and reinstatement was observed. Using multiple regression analysis, we found that measures of social interaction were significant predictors of nicotine intake and reinstatement of drug seeking in both males and females. Furthermore, measures of depression were predictors of nicotine intake in both males and females, anxiety was a predictor only in males and response to novelty was a predictor only in females. In males, measures of both depression and anxiety predicted nicotine reinstatement. Together, these data supported the ideas that genetically determined propensities for emotional and social phenotypes are significant determinants for nicotine-reinforced behavior, and that the HS rat is a suitable tool for dissecting genetic mechanisms that may underlie the interaction between social behavior, anxiety, depression and smoking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.