ArticleBMC microbiology2013
Hyperosmotic response of streptococcus mutans: from microscopic physiology to transcriptomic profile.
Article in BMC microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Molecular Regulation of Virulence and Dental Biofilm Formation in Streptococcus mutans: Unravelling the Crosstalk Between the VicRK and LiaSR Two-Component Systems.Molecular oral microbiology · 2026Review
- In vitro evaluation of tolerance ability of cross-kingdom biofilm towards oral dynamic fluctuations.BMC oral health · 2025Article
- Article
- Novel Bioactive Nanocomposites Containing Calcium Fluoride and Calcium Phosphate with Antibacterial and Low-Shrinkage-Stress Capabilities to Inhibit Dental Caries.Bioengineering (Basel, Switzerland) · 2023Article
- Medical and Dental Applications of Titania Nanoparticles: An Overview.Nanomaterials (Basel, Switzerland) · 2022Review
- Influence of Fluoride-ResistantFrontiers in cellular and infection microbiology · 2022Article
- The suppression effect of SCH-79797 onJournal of oral microbiology · 2022Article
- Responses of Acinetobacter baumannii Bound and Loose Extracellular Polymeric Substances to Hyperosmotic Agents Combined with or without Tobramycin: An Atomic Force Microscopy Study.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Plasticity of the Pyruvate Node Modulates Hydrogen Peroxide Production and Acid Tolerance in Multiple Oral Streptococci.Applied and environmental microbiology · 2018Article
- Osmotic Compounds Enhance Antibiotic Efficacy against Acinetobacter baumannii Biofilm Communities.Applied and environmental microbiology · 2017Article
- A novel plant E3 ligase stabilizes Escherichia coli heat shock factor σScientific reports · 2017Article
- Vancomycin and maltodextrin affect structure and activity of Staphylococcus aureus biofilms.Biotechnology and bioengineering · 2015Article
- Streptococcus mutans copes with heat stress by multiple transcriptional regulons modulating virulence and energy metabolism.Scientific reports · 2015Article
- Effect of sodium chloride on gene expression ofJournal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral streptococci metabolize carbohydrate to produce organic acids, which not only decrease the environmental pH, but also increase osmolality of dental plaque fluid due to tooth demineralization and consequent calcium and phosphate accumulation. Despite these unfavorable environmental changes, the bacteria continue to thrive. The aim of this study was to obtain a global view on strategies taken by Streptococcus mutans to deal with physiologically relevant elevated osmolality, and perseveres within a cariogenic dental plaque.
resultsWe investigated phenotypic change of S. mutans biofilm upon hyperosmotic challenge. We found that the hyperosmotic condition was able to initiate S. mutans biofilm dispersal by reducing both microbial content and extracellular polysaccharides matrix. We then used whole-genome microarray with quantitative RT-PCR validation to systemically investigate the underlying molecular machineries of this bacterium in response to the hyperosmotic stimuli. Among those identified 40 deferentially regulated genes, down-regulation of gtfB and comC were believed to be responsible for the observed biofilm dispersal. Further analysis of microarray data showed significant up-regulation of genes and pathways involved in carbohydrate metabolism. Specific genes involved in heat shock response and acid tolerance were also upregulated, indicating potential cross-talk between hyperosmotic and other environmental stress.
conclusionsHyperosmotic condition induces significant stress response on S. mutans at both phenotypic and transcriptomic levels. In the meantime, it may take full advantage of these environmental stimuli to better fit the fluctuating environments within oral cavity, and thus emerges as numeric-predominant bacterium under cariogenic conditions.
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