ArticleRadiation oncology (London, England)2013
CBCT-based volumetric and dosimetric variation evaluation of volumetric modulated arc radiotherapy in the treatment of nasopharyngeal cancer patients.
Article in Radiation oncology (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 25 citations in OpenAlex.
- Predicting the benefit of adaptive radiotherapy in head and neck Cancer using cone-beam computed tomography.Physics and imaging in radiation oncology · 2026Article
- Clinical application of cone beam CT in intensity-modulated radiotherapy for the moderate to severe thyroid-associated ophthalmopathy.Journal of applied clinical medical physics · 2025Article
- Anatomical and dosimetric variations during volumetric modulated arc therapy in patients with locally advanced nasopharyngeal carcinoma after induction therapy: Implications for adaptive radiation therapy.Clinical and translational radiation oncology · 2024Article
- Review of Osteoradionecrosis of the Jaw: Radiotherapy Modality, Technique, and Dose as Risk Factors.Journal of clinical medicine · 2023Review
- Feasibility of Continual Deep Learning-Based Segmentation for Personalized Adaptive Radiation Therapy in Head and Neck Area.Cancers · 2021Article
- Cone-beam CT radiomics features might improve the prediction of lung toxicity after SBRT in stage I NSCLC patients.Thoracic cancer · 2020Article
- Radiotherapy for Head and Neck Cancer: Evaluation of Triggered Adaptive Replanning in Routine Practice.Frontiers in oncology · 2020Article
- Adaptive radiotherapy for head and neck cancer reduces the requirement for rescans during treatment due to spinal cord dose.Radiation oncology (London, England) · 2019Article
- Commissioning an in-room mobile CT for adaptive proton therapy with a compact proton system.Journal of applied clinical medical physics · 2018Article
- The Value of CBCT-based Tumor Density and Volume Variations in Prediction of Early Response to Chemoradiation Therapy in Advanced NSCLC.Scientific reports · 2017Article
- Article
- Comparison of Deep Learning-Based Auto-Segmentation Results on Daily Kilovoltage, Megavoltage, and Cone Beam CT Images in Image-Guided Radiotherapy.Technology in cancer research & treatmentArticle
- Study of Variation in Dose Calculation Accuracy Between kV Cone-Beam Computed Tomography and kV fan-Beam Computed Tomography.Journal of medical physicsArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the anatomic and dosimetric variations of volumetric modulated arc therapy (VMAT) in the treatment of nasopharyngeal cancer (NPC) patients based on weekly cone beam CT (CBCT). MATERIALS AND
methodsTen NPC patients treated by VMAT with weekly CBCT for setup corrections were reviewed retrospectively. Deformed volumes of targets and organs at risk (OARs) in the CBCT were compared with those in the planning CT. Delivered doses were recalculated based on weekly CBCT and compared with the planned doses.
resultsNo significant volumetric changes on targets, brainstem, and spinal cord were observed. The average volumes of right and left parotid measured from the fifth CBCT were about 4.4 and 4.5 cm3 less than those from the first CBCT, respectively. There were no significant dose differences between average planned and delivered doses for targets, brainstem and spinal cord. For right parotid, the delivered mean dose was 10.5 cGy higher (p = 0.004) than the planned value per fraction, and the V26 and V32 increased by 7.5% (p = 0.002) and 7.4% (p = 0.01), respectively. For the left parotid, the D50 (dose to the 50% volume) was 8.8 cGy higher (p = 0.03) than the planned values per fraction, and the V26 increased by 8.8% (p = 0.002).
conclusionWeekly CBCTs were applied directly to study the continuous volume changes and resulting dosimetric variations of targets and OARs for NPC patients undergoing VMAT. Significant volumetric and dosimetric variations were observed for parotids. Replanning after 30 Gy will benefit the protection on parotids.
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